Role of L-Arginine, a Substrate of Nitric Oxide Biosynthesis, on Intestinal Ischemia-Reperfusion in Rabbits

Role of L-Arginine, a Substrate of Nitric Oxide Biosynthesis, on Intestinal Ischemia-Reperfusion in Rabbits

Autor Taha, M. O. Autor UNIFESP Google Scholar
Miranda-Ferreira, R. Google Scholar
Paez, R. P. Google Scholar
Simoes, R. S. Google Scholar
Boin, H. C. Google Scholar
Martins, I. A. Google Scholar
Versage, P. F. V. Google Scholar
Silva, H. F. M. Google Scholar
Penzo, L. D. P. R. S. Google Scholar
Fagundes, A. L. N. Google Scholar
Oliveira, I. Google Scholar
Caricati-Neto, A. Google Scholar
Monteiro, H. P. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
UFGD
Resumo To study whether treatment with L-arginine (ARG), a substrate of nitric oxide biosynthesis, attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rabbits treated with ARG (100 mg . kg(-1), intravenously) or saline solution (SS) prior to I (60 minutes) by occlusion of superior mesenteric artery and/or during R (120 minutes). After I or I/R, 2-cm jejunal segments were isolated and mounted in an organ bath to study of neurogenic contractions stimulated by electrical pulses or KO using a digital recording system. Thin jejunal slices were stained (hematoxylin and eosin) for analysis by optical microscopy. Compared to the sham group, jejunal contractions were similar in I + ARG, but reduced in I + SS, I/R + SS, and I/R + ARG groups. the jejunal enteric nerves were damaged in I + SS, I/R + SS, and I/R + ARG, but not in I + ARG group, suggesting that ARG can attenuate intestinal dysfunctions due to I, but not to R.
Idioma Inglês
Data de publicação 2010-03-01
Publicado em Transplantation Proceedings. New York: Elsevier B.V., v. 42, n. 2, p. 448-450, 2010.
ISSN 0041-1345 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 448-450
Fonte http://dx.doi.org/10.1016/j.transproceed.2010.01.023
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276051400011
Endereço permanente http://repositorio.unifesp.br/handle/11600/32348

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