Intestinal Ischemia-Reperfusion Is Attenuated by Treatment With Atenolol in Rabbits

Intestinal Ischemia-Reperfusion Is Attenuated by Treatment With Atenolol in Rabbits

Autor Taha, M. O. Autor UNIFESP Google Scholar
Miranda-Ferreira, R. Google Scholar
Simoes, R. S. Google Scholar
Oliveira, I. Google Scholar
Modaelli-Filho, M. L. Google Scholar
Magalhaes-Junior, W. F. Google Scholar
Souza, E. S. Google Scholar
Lemos, J. A. S. Google Scholar
Simoes, M. C. Google Scholar
Caricati-Neto, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
UFGD
Resumo To study whether treatment with the beta-blocker atenolol (AT) attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rabbits were treated with AT (1 mg . kg(-1), introvenously) or saline solution (SS) prior to I (60 minutes), which was produced by occlusion of the superior mesenteric artery, and/or R (120 minutes). After I or I/R, 2-cm jejunal segments were mounted in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained hematoxylin and eosin for analysis by optical microscopy. Compared to the sham group, the jejunal contractions were similar in the I + AT and the I/R + AT groups, but reduced in the I + SS and the I/R + SS groups. the jejunal enteric nerves were damaged in the I + SS and the I/R + SS groups, but not in the I + AT and the I/R + AT. These results suggest that AT may attenuate intestinal dysfunction caused by I and I/R.
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data 2010-03-01
Publicado em Transplantation Proceedings. New York: Elsevier B.V., v. 42, n. 2, p. 451-453, 2010.
ISSN 0041-1345 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 451-453
Fonte http://dx.doi.org/10.1016/j.transproceed.2010.01.020
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276051400012
URI http://repositorio.unifesp.br/handle/11600/32347

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