Role of Adenosine on Intestinal Ischemia-Reperfusion Injury in Rabbits

Role of Adenosine on Intestinal Ischemia-Reperfusion Injury in Rabbits

Autor Taha, M. O. Autor UNIFESP Google Scholar
Miranda-Ferreira, R. Google Scholar
Simoes, R. S. Google Scholar
Abrao, M. S. Google Scholar
Oliveira-Junior, I. S. Google Scholar
Monteiro, H. P. Google Scholar
Santos, J. M. Google Scholar
Rodrigues, P. H. Google Scholar
Rodrigues, J. V. Google Scholar
Alves, A. E. M. Google Scholar
Nascimento, E. C. Google Scholar
Silva, T. L. B. Google Scholar
Zeviani, W. M. Google Scholar
Caricati-Neto, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
UFGD
Resumo To study if the treatment with adenosine (ADO), an agonist of adenosine receptors, attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), we treated rabbits with ADO (15 mg . kg(-1), intravenously) or saline solution (SS) to I (60 minutes) before occlusion of superior mesenteric artery and/or R (120 mm) After I or I/R, isolated jejuna! segments (2 cm) were mounted in an organ bath to study nerve-mediated contractions stimulated by electrical pulses or KO using a digital recording system. Thin jejunal slices were stained (hematoxylin and eosin) for analysis by optical microscopy. Compared to the sham group, the jejunal contractions were similar in I + ADO, but reduced in I + SS, I/R + SS, and I/R + ADO groups. We concluded that the jejunal enteric nerves were damaged in I + SS, I/R + SS, and I/R + ADO, but not in I + ADO group. These results suggested that ADO attenuated intestinal dysfunction due to I, but not to R.
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data 2010-03-01
Publicado em Transplantation Proceedings. New York: Elsevier B.V., v. 42, n. 2, p. 454-456, 2010.
ISSN 0041-1345 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 454-456
Fonte http://dx.doi.org/10.1016/j.transproceed.2010.01.019
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276051400013
URI http://repositorio.unifesp.br/handle/11600/32346

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