Outcomes of laser thermal therapy for recurrent head and neck cancer

Outcomes of laser thermal therapy for recurrent head and neck cancer

Autor Sercarz, Joel A. Google Scholar
Bublik, Michael Google Scholar
Joo, Jayne Google Scholar
Paiva, Paulo B. Autor UNIFESP Google Scholar
Areco, Kelsy N. Autor UNIFESP Google Scholar
Brandalise, Maria Helena Autor UNIFESP Google Scholar
Loh, Christopher Google Scholar
Masterman-Smith, Michael Google Scholar
Paiva, Marcos B. Google Scholar
Instituição Univ Calif Los Angeles
Univ Miami
Universidade Federal de São Paulo (UNIFESP)
Resumo OBJECTIVE: To review the outcomes of a phase II study using laser-induced thermal therapy (LIFT) as a palliative treatment for 106 patients with recurrent head and neck tumors.STUDY DESIGN: Retrospective study.SETTING: Tertiary hospital in the United States.SUBJECTS and METHODS: the primary endpoints were tumor response and survival. Prognostic values were assessed by the Kaplan-Meier method.RESULTS: the best results were seen in oral cavity tumors, in which mean survival was 29.1 months, as compared to neck tumors (mean 14.4 +/- 6.9 months; range 7.5-20.7 months; with a 95% confidence interval). Further analysis showed that clinical factors such as gender, smoking, and alcohol use were not indicators of poor prognosis, whereas neck disease and tumor stage at first treatment were relevant factors.CONCLUSION: in this study, 40 out of 106 patients treated by LITT remained alive at the end of our follow-up, and a complete response was seen in 24 (22.6%) patients. the highest response rate was seen in oral cavity tumors, which suggests that tumor location at this site may be a predictor of favorable outcome with LITT. (c) 2010 American Academy of Otolaryngology Head and Neck Surgery Foundation. All rights reserved.
Idioma Inglês
Financiador Division of Head and Neck Surgery, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, National Institutes of Health
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento Division of Head and Neck Surgery, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, National Institutes of Health: K23CA88921
Division of Head and Neck Surgery, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, National Institutes of Health: K22CA131509
FAPESP: 08/54714-6
Data de publicação 2010-03-01
Publicado em Otolaryngology-head and Neck Surgery. London: Sage Publications Ltd, v. 142, n. 3, p. 344-350, 2010.
ISSN 0194-5998 (Sherpa/Romeo, fator de impacto)
Publicador Sage Publications Ltd
Extensão 344-350
Fonte http://dx.doi.org/10.1016/j.otohns.2009.11.019
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276574600009
Endereço permanente http://repositorio.unifesp.br/handle/11600/32343

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