The impact of tonic immobility reaction on the prognosis of posttraumatic stress disorder

The impact of tonic immobility reaction on the prognosis of posttraumatic stress disorder

Author Lima, Alessandra A. Google Scholar
Fiszman, Adriana Google Scholar
Marques-Portella, Carla Google Scholar
Mendlowicz, Mauro V. Google Scholar
Coutinho, Evandro S. F. Google Scholar
Maia, Deborah C. B. Google Scholar
Berger, William Google Scholar
Rocha-Rego, Vanessa Google Scholar
Volchan, Eliane Google Scholar
Mari, Jair J. Autor UNIFESP Google Scholar
Figueira, Ivan Google Scholar
Institution Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal Fluminense (UFF)
Universidade Federal de São Paulo (UNIFESP)
Abstract Tonic immobility is the last defense reaction to entrapment by a predator. in humans, peritraumatic tonic immobility was correlated with PTSD severity and poor response to treatment. This study compared the role of peritraumatic dissociation, panic physical symptoms and tonic immobility as predictors of response to standard pharmacotherapy for PTSD. Thirty-six PTSD patients underwent a naturalistic pharmacological treatment. the Posttraumatic Stress Disorder Checklist - Civilian Version (PCL-C) and the Clinical Global Impressions Severity of Illness item scores (CGI-S) were employed at baseline and endpoint to examine treatment outcome. Peritraumatic reactions were assessed using the Physical Reactions Subscale, the Peritraumatic Dissociative Experiences Questionnaire and four motor questions of the Tonic Immobility Scale. After controlling for confounders, tonic immobility was the best predictor of a poor response to treatment, either considering the PCL-C or the CGI-S scores. Tonic immobility seems to have a greater negative impact on PTSD prognosis than peritraumatic panic or dissociation. Additional translational and clinical research may inform about particular mechanisms underlying tonic immobility and open new avenues for prevention and treatment of PTSD. (C) 2009 Elsevier B.V. All rights reserved.
Keywords PTSD
Peritraumatic reactions
Tonic immobility
Drug therapy
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Millennium Institute
Confederacao Nacional do Comercio
Grant number Millennium Institute: 420122
Millennium Institute: 2005-2
Date 2010-03-01
Published in Journal of Psychiatric Research. Oxford: Pergamon-Elsevier B.V., v. 44, n. 4, p. 224-228, 2010.
ISSN 0022-3956 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 224-228
Access rights Closed access
Type Article
Web of Science ID WOS:000276008200006

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account