Infections in heart transplant recipients in Brazil: the challenge of Chagas' disease

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dc.contributor.author Godoy, Henrique L. [UNIFESP]
dc.contributor.author Guerra, Carla M. [UNIFESP]
dc.contributor.author Viegas, Ruy F. [UNIFESP]
dc.contributor.author Dinis, Rosiane Z. [UNIFESP]
dc.contributor.author Branco, Joao N. [UNIFESP]
dc.contributor.author Neto, Vicente A. [UNIFESP]
dc.contributor.author Almeida, Dirceu R. [UNIFESP]
dc.date.accessioned 2016-01-24T13:59:24Z
dc.date.available 2016-01-24T13:59:24Z
dc.date.issued 2010-03-01
dc.identifier http://dx.doi.org/10.1016/j.healun.2009.08.006
dc.identifier.citation Journal of Heart and Lung Transplantation. New York: Elsevier B.V., v. 29, n. 3, p. 286-290, 2010.
dc.identifier.issn 1053-2498
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/32333
dc.description.abstract BACKGROUND: Despite the high incidence of infections after heart transplantation, there is limited information about its epidemiology in patients from countries where Chagas' disease is endemic.METHODS: We analyzed the occurrence of infections in 126 patients aged older than 18 years who underwent transplantation from 1986 through 2007 at a Brazilian University Hospital and who survived at least 48 hours.RESULTS: Heart failure diagnoses before transplantation were idiopathic dilated cardiomyopathy (38.6%), Chagas' disease (34.9%), coronary artery disease (19.8%), and others (6.3%). the respiratory tract was the most common site of infections (40.9%), followed by surgical wound site (18.1%). Trypanosoma cruzi reactivations occurred in, 38.8% of Chagas' disease patients: 47.0% had myocarditis, 23.5% had skin lesions, and 29.4% had both. New-onset ventricular dysfunction was observed in 47.0%, with complete response after specific treatment, and 41.0% were asymptomatic cases, diagnosed by routine endomyocardial biopsies. No patient died from such events. No differences in survival were found after 5 years of follow-up between recipients with and without Chagas' disease (p = 0.231).CONCLUSIONS: in a heart transplant population from a developing country, infectious complications occurred at a high rate. Tropical illnesses were uncommon, except for the high rate of Chagas' disease reactivations. Despite that, the overall outcome of these patients was similar to that of recipients with other cardiomyopathies. J Heart Lung Transplant 2010;29:286-90 (C) 2010 International Society for Heart and Lung Transplantation. All rights reserved. en
dc.format.extent 286-290
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Journal of Heart and Lung Transplantation
dc.rights Acesso restrito
dc.subject Chagas' disease en
dc.subject Trypanosoma cruzi en
dc.subject immunosuppression en
dc.subject infections en
dc.subject allopurinol en
dc.title Infections in heart transplant recipients in Brazil: the challenge of Chagas' disease en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Med, Div Cardiol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Med, Div Infect Dis, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Inst Trop Med, Med Invest Lab Parasitol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Med, Div Cardiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Med, Div Infect Dis, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Inst Trop Med, Med Invest Lab Parasitol, São Paulo, Brazil
dc.identifier.doi 10.1016/j.healun.2009.08.006
dc.description.source Web of Science
dc.identifier.wos WOS:000276005200010



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