Human cytomegalovirus reinfection is associated with intrauterine transmission in a highly cytomegalovirus-immune maternal population

Human cytomegalovirus reinfection is associated with intrauterine transmission in a highly cytomegalovirus-immune maternal population

Autor Yamamoto, Aparecida Yulie Google Scholar
Mussi-Pinhata, Marisa Marcia Google Scholar
Boppana, Suresh B. Google Scholar
Novak, Zdenek Google Scholar
Wagatsuma, Virginia M. Google Scholar
Oliveira, Patricia de Frizzo Google Scholar
Duarte, Geraldo Google Scholar
Britt, William J. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Alabama
Resumo OBJECTIVE: To determine contribution of reinfection with new strains of cytomegalovirus in cytomegalovirus seromimmune women to incidence of congenital cytomegalovirus infection.STUDY DESIGN: in 7848 women studied prospectively for congenital cytomegalovirus infection from a population with near universal cytomegalovirus seroimmunity, sera from 40 mothers of congenitally infected infants and 109 mothers of uninfected newborns were analyzed for strain-specific anticytomegalovirus antibodies.RESULTS: All women were cytomegalovirus seroimmune at first prenatal visit. Reactivity for 2 cytomegalovirus strains was found in 14 of 40 study mothers and in 17 of 109 control mothers at first prenatal visit (P=.009). Seven of 40 (17.5%) study women and 5 of 109 (4.6%) controls (P=.002) acquired antibodies reactive with new cytomegalovirus strains during pregnancy. Evidence of infection with more than 1 strain of cytomegalovirus before or during current pregnancy occurred in 21 of 40 study mothers and 22 of 109 controls (P<.0001).CONCLUSION: Maternal reinfection by new strains of cytomegalovirus is a major source of congenital infection in this population.
Palavra-chave congenital cytomegalovirus infection
cytomegalovirus reinfection
maternal reinfection with cytomegalovirus
Idioma Inglês
Financiador National Institutes of Health
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento National Institutes of Health: NIAID AI 49537
National Institutes of Health: R03 TW006480
National Institutes of Health: NIDCD DC04162
FAPESP: 02/04166-6
Data de publicação 2010-03-01
Publicado em American Journal of Obstetrics and Gynecology. New York: Mosby-Elsevier, v. 202, n. 3, 8 p., 2010.
ISSN 0002-9378 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 8
Fonte http://dx.doi.org/10.1016/j.ajog.2009.11.018
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000275516900032
Endereço permanente http://repositorio.unifesp.br/handle/11600/32327

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