Author |
Mello, Valderez Raposo de
![]() Rodrigues, Maira Tinte ![]() Mastrocinque, Tais Helena ![]() Laranjo Martins, Simone Paiva ![]() Braga de Andrade, Olberes Vitor ![]() Medeiros Guidoni, Eliana Biondi ![]() Scheffer, Daniel Kashiwamura ![]() Martini Filho, Dino ![]() Toporovski, Julio ![]() Benini, Vanda ![]() |
Institution | Universidade Federal de São Paulo (UNIFESP) Santa Casa São Paulo |
Abstract | The purpose of this study was to assess the results of therapy with mycophenolate mofetil (MMF) in children with idiopathic nephrotic syndrome (INS) who were both steroid- and cyclophosphamide-resistant. Treatment lasted a minimum of 6 months, and follow-up data were collected over a 2-year period. the children were divided into two groups: Group 1 (n = 34) comprised patients who had received cyclosporine A (CsA) before the initiation of MMF therapy; Group 2 (n = 18) comprised patients who received only MMF. Among the 34 patients of Group 1, complete and partial remission were achieved in seven (20.6%) and 13 patients (38.6%), respectively; there was no response in 14 patients (41.2%). Among the 18 patients in Group 2, complete and partial remission occurred in five (27.8%) and six (33.3%) patients, respectively; there was no response in seven patients (38.9%). Eight patients developed chronic kidney disease. the main side-effects were gastrointestinal complaints (n = 11, 21%), recurring severe infections (n = 1, 1.9%), and mild thrombocytopenia/leucopenia (n = 1, 1.9%). MMF proved to be therapeutically effective in 59.5% of the cases. These beneficial effects need to be confirmed in studies with a long-term follow-up after discontinuation of the treatment. Our statistical analysis of the results of therapy with MMF did not reveal any significant difference between its use alone or following CsA administration. |
Keywords |
Cyclophosphamide resistant
Cyclosporine A Glomerulopathies Glomerulosclerosis Mycophenolate mofetil Nephrotic syndrome Steroid resistant |
Language | English |
Date | 2010-03-01 |
Published in | Pediatric Nephrology. New York: Springer, v. 25, n. 3, p. 453-460, 2010. |
ISSN | 0931-041X (Sherpa/Romeo, impact factor) |
Publisher | Springer |
Extent | 453-460 |
Origin |
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Access rights | Closed access |
Type | Article |
Web of Science ID | WOS:000273950600008 |
URI | http://repositorio.unifesp.br/handle/11600/32319 |
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