Endoscopic ultrasound-guided celiac plexus neurolysis using a reverse phase polymer

Endoscopic ultrasound-guided celiac plexus neurolysis using a reverse phase polymer

Author Obstein, Keith L. Google Scholar
Martins, Fernanda P. Autor UNIFESP Google Scholar
Fernandez-Esparrach, Gloria Google Scholar
Thompson, Christopher C. Google Scholar
Institution Brigham & Womens Hosp
Universidade Federal de São Paulo (UNIFESP)
Hosp Clin Barcelona
Abstract AIM: To assess the feasibility of endoscopic ultrasound (EUS)-guided celiac plexus neurolysis (CPN) using a poloxamer.METHODS: in this prospective evaluation, six Yorkshire pigs underwent EUS-guided CPN. Three received an injection of 10 mL of 0.25% Lidocaine plus methylene blue (group 1) and three received an injection of 10 mL of 0.25% Lidocaine plus blue colored poloxamer (PS137-25) (group 2). Necropsy was performed immediately after the animals were sacrificed. the abdominal and pelvic cavities were examined for the presence of methylene blue and the blue colored poloxamer.RESULTS: EUS-guided CPN was successfully performed in all 6 pigs without immediate complication. Methylene blue was identified throughout the peritoneal and retroperitoneal cavity in group 1. the blue colored poloxamer was found in the retroperitoneal cavity immediately adjacent to the aorta, in the exact location of the celiac plexus in group 2.CONCLUSION: EUS-guided CPN using a reverse phase polymer in a non-survival porcine model was technically feasible. the presence of a poloxamer gel at the site of the celiac plexus at necropsy indicates a precise delivery of the neurolytic agent. (C) 2010 Baishideng. All rights reserved.
Keywords Celiac plexus neurolysis
Celiac plexus blockade
Endoscopic ultrasound
Polymer
Language English
Sponsor Generalitat de Catalunya (AGAUR)
Grant number Generalitat de Catalunya (AGAUR): BE-100022
Date 2010-02-14
Published in World Journal of Gastroenterology. Beijing: W J G Press, v. 16, n. 6, p. 728-731, 2010.
ISSN 1007-9327 (Sherpa/Romeo, impact factor)
Publisher W J G Press
Extent 728-731
Origin http://dx.doi.org/10.3748/wjg.v16.i6.728
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000274459200010
URI http://repositorio.unifesp.br/handle/11600/32269

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