Persistence of vaccine immunity against hepatitis B virus and response to revaccination in vertically HIV-infected adolescents on HAART

Persistence of vaccine immunity against hepatitis B virus and response to revaccination in vertically HIV-infected adolescents on HAART

Author Pessoa, Silvana D. Autor UNIFESP Google Scholar
Miyamoto, Maristela Autor UNIFESP Google Scholar
Ono, Erika Autor UNIFESP Google Scholar
Gouvêa, Aida de Fátima Thomé Barbosa Autor UNIFESP Google Scholar
Moraes-Pinto, Maria Isabel de Autor UNIFESP Google Scholar
Succi, Regina C. M. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Humoral immune response to vaccine antigens is known to be reduced in perinatally HIV-infected children. Lymphocyte immunophenotyping, humoral immunity to hepatitis B after primary immunization and response to revaccination were evaluated in 40 HIV-infected adolescents on HAART and 23 healthy age-matched controls. Anti-HBs antibody levels >= 10 mIU/mL were found in 18/40 (40.5%) of the HIV-infected adolescents and 18/23 (78.3%) of the HIV-negative adolescents from Control group. Adolescents of HIV group with anti-HBs >= 10 mIU/mL presented a higher CD4+ T cell percentage, higher naive and central memory CD8+ T cell percentages and lower immune activation markers. After revaccination, 12/18 (66.7%) adolescents of HIV group responded. Those adolescents who did not respond to revaccination presented a lower CD4+ T cell percentage, higher immune activation markers and more frequently detectable HIV viral load. We concluded that lower immune activation, higher CD4+ T cell percentage and better control of HIV replication may be associated with hepatitis B vaccine response. (C) 2009 Elsevier B.V. All rights reserved.
Keywords Hepatitis B vaccine
HIV
CD38
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 04/15934-0
Date 2010-02-10
Published in Vaccine. Oxford: Elsevier B.V., v. 28, n. 6, p. 1606-1612, 2010.
ISSN 0264-410X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1606-1612
Origin http://dx.doi.org/10.1016/j.vaccine.2009.11.045
Access rights Closed access
Type Article
Web of Science ID WOS:000275301900026
URI http://repositorio.unifesp.br/handle/11600/32266

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