STORAGE RESULTS in LOSS of the ANTIGENOTOXIC PROPERTIES of LENTINULA EDODES (SHIITAKE MUSHROOM) and DEVELOPMENT of in VIVO GENOTOXICITY

Show simple item record

dc.contributor.author Alves de Lima, Patricia L.
dc.contributor.author Ribeiro, Daniel A. [UNIFESP]
dc.contributor.author Sugui, Marina M.
dc.contributor.author Terezan, Ana Paula
dc.contributor.author Domingues, Maria Aparecida C.
dc.contributor.author Filho, E. R.
dc.contributor.author Azevedo, Luciana
dc.contributor.author Salvadori, Daisy M. F.
dc.contributor.author Ribeiro, Lucia R.
dc.date.accessioned 2016-01-24T13:59:18Z
dc.date.available 2016-01-24T13:59:18Z
dc.date.issued 2010-02-01
dc.identifier http://dx.doi.org/10.1111/j.1745-4514.2009.00275.x
dc.identifier.citation Journal of Food Biochemistry. Malden: Wiley-Blackwell Publishing, Inc, v. 34, n. 1, p. 206-228, 2010.
dc.identifier.issn 0145-8884
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/32254
dc.description.abstract In this study, we have investigated the stability of the antigenotoxic properties of dried of Lentinula edodes (Berk.) Singer mushroom powder stored at room and at -20C. Mice were pretreated by gavage for 15 consecutive days with 0.6 mL/day of an aqueous extract of dried L. edodes powder prepared at 60C. On day 15, the mice were intraperitoneally injected with 50 mg/kg N-ethyl-N-nitrosourea (ENU); 3 h later, peripheral blood was withdrawn from the animals and used to evaluate DNA damage using the comet assay. the mice were sacrificed 24 h after the ENU treatment and the bone marrow used to measure the frequency of micronucleated polychromatic erythrocytes. the results indicated that storage at both room temperature and at -20C significantly reduced the antigenotoxic effects of the mushroom powder. in addition, whereas freshly dried mushroom powder was nongenotoxic, storage of the powder at -20C resulted in genotoxic activity (P < 0.05). Taken together, our data indicate that constituents of L. edodes powder are altered during storage, resulting in both genotoxicity and a reduction in antigenotoxicity. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 206-228
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Journal of Food Biochemistry
dc.rights Acesso restrito
dc.title STORAGE RESULTS in LOSS of the ANTIGENOTOXIC PROPERTIES of LENTINULA EDODES (SHIITAKE MUSHROOM) and DEVELOPMENT of in VIVO GENOTOXICITY en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Federal de São Carlos (UFSCar)
dc.contributor.institution Univ Fed Alfenas
dc.description.affiliation UNESP, Fac Med, Dept Patol, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biociencias, UNIFESP, São Paulo, Brazil
dc.description.affiliation Univ Fed Sao Carlos, Dept Quim, São Paulo, Brazil
dc.description.affiliation Univ Fed Alfenas, Dept Nutr, Alfenas, MG, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biociencias, UNIFESP, São Paulo, Brazil
dc.identifier.doi 10.1111/j.1745-4514.2009.00275.x
dc.description.source Web of Science
dc.identifier.wos WOS:000274200900016



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account