Dietary omega-3 fatty acid and omega-3: omega-6 fatty acid ratio predict improvement in glucose disturbances in Japanese Brazilians

Dietary omega-3 fatty acid and omega-3: omega-6 fatty acid ratio predict improvement in glucose disturbances in Japanese Brazilians

Author Sartorelli, Daniela S. Google Scholar
Damiao, Renata Autor UNIFESP Google Scholar
Chaim, Rita Google Scholar
Hirai, Amelia Autor UNIFESP Google Scholar
Gimeno, Suely G. A. Autor UNIFESP Google Scholar
Ferreira, Sandra R. G. Google Scholar
Japanese Brazilian Diabet Study Gr Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Sagiado Coracao
Abstract Objective: We investigated whether lifestyle-induced changes in dietary fat quality are related to Improvements on glucose metabolism disturbances in Japanese Brazilians at high risk of type 2 diabetesMethods: One hundred forty-eight first- and second-generation subjects with impaired glucose tolerance or impaired fasting glycemia who attended a lifestyle intervention program for 12 mo were studied in the city of Bauru. State of São Paulo, Brazil Dietary fatty acid intakes at baseline and after 12 mo were estimated using three 24-h recalls. the effect of dietary fat intake on glucose metabolism was investigated by multiple logistic regression modelsResults: At baseline, mean standard deviation age and body mass index were 60 II y and 25 5 4.2 kg/m2, respectively After 12 mo. 92 subjects had normal plasma glucose levels and 56 remained in prediabetic conditions. Using logistic regression models adjusted for age, gender, generation, basal intake of explanatory nutrient, energy intake, physical activity, and waist circumference, the odds ratios (95% confidence intervals) for reversion to normoglycemia were 3 14 (1 22-8 10) in the second wrote of total w-3 fatty acid, 4 26 (1.34-13 57) in the second tunic of eicosapentaenoic acid, and 280 (1 10-7.10) in the second tertile of linolenic acid. Similarly. subjects in the highest wrote of w-3.w-6 fatty acid ratio showed a higher chance of improving glucose disturbances (2 51, 1.01-6.37)Conclusions: Our findings support the evidence of an independent protective effect of omega-3 fatty acid and of a higher omega-3:omega-6 fatty acid ratio on the glucose metabolism of high-risk individuals (C) 2010 Elsevier Inc All rights reserved.
Keywords Dietary fatty acids
omega-3 fatty acid
omega-3 to omega-6 fatty acids ratio
Glucose metabolism
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number CNPq: 505845/2004-0
CNPq: 150943/2005-9
FAPESP: 05/59178-7
FAPESP: 05/60290-6
Date 2010-02-01
Published in Nutrition. New York: Elsevier B.V., v. 26, n. 2, p. 184-191, 2010.
ISSN 0899-9007 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 184-191
Access rights Closed access
Type Article
Web of Science ID WOS:000276331900007

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