Maternal Age at Birth and Childhood Type 1 Diabetes: A Pooled Analysis of 30 Observational Studies

Maternal Age at Birth and Childhood Type 1 Diabetes: A Pooled Analysis of 30 Observational Studies

Author Cardwell, Chris R. Google Scholar
Stene, Lars C. Google Scholar
Joner, Geir Google Scholar
Bulsara, Max K. Google Scholar
Cinek, Ondrej Google Scholar
Rosenbauer, Joachim Google Scholar
Ludvigsson, Johnny Google Scholar
Jane, Mireia Google Scholar
Svensson, Jannet Google Scholar
Goldacre, Michael J. Google Scholar
Waldhoer, Thomas Google Scholar
Jarosz-Chobot, Przemyslawa Google Scholar
Gimeno, Suely Godoy Agostinho Autor UNIFESP Google Scholar
Chuang, Lee-Ming Google Scholar
Parslow, Roger C. Google Scholar
Wadsworth, Emma J. K. Google Scholar
Chetwynd, Amanda Google Scholar
Pozzilli, Paolo Google Scholar
Brigis, Girts Google Scholar
Urbonaite, Brone Google Scholar
Sipetic, Sandra Google Scholar
Schober, Edith Google Scholar
Devoti, Gabriele Google Scholar
Ionescu-Tirgoviste, Constantin Google Scholar
Beaufort, Carine E. de Google Scholar
Stoyanov, Denka Google Scholar
Buschard, Karsten Google Scholar
Patterson, Chris C. Google Scholar
Institution Queens Univ Belfast
Norwegian Inst Publ Hlth
Oslo Univ Hosp
Univ Oslo
Univ Notre Dame
Charles Univ Prague
Univ Dusseldorf
Linkoping Univ
Dept Hlth
Glostrup Univ Hosp
Univ Oxford
Med Univ Vienna
Med Univ Silesia
Universidade Federal de São Paulo (UNIFESP)
Natl Taiwan Univ Hosp
Univ Leeds
Cardiff Univ
Univ Lancaster
Univ Campus Biomed
Riga Stradins Univ
Kaunas Univ Med
Univ Belgrade
Univ Lecce
N Paulescu Inst Diabet
Pediat Clin
Childrens Diabet Ctr
Rigshosp
Abstract OBJECTIVE-The aim if the study was to investigate whether children born to older mothers have an increased risk of type 1 diabetes by performing a pooled analysis of previous studies using individual patient data to adjust for recognized confounders.RESEARCH DESIGN and METHODS-Relevant studies published before June 2009 were identified from MEDLINE, Web of Science, and EMBASE. Authors of studies were contacted and asked to provide individual patient data or conduct prespecified analyses. Risk estimates of type 1 diabetes by maternal age were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were used to derive combined odds ratios and to investigate heterogeneity among studies.RESULTS-Data were available for 5 cohort and 25 case-control studies, including 14,724 cases of type 1 diabetes. Overall, there was, on average, a 5% (95% CI 2-9) increase in childhood type 1 diabetes odds per 5-year increase in maternal age (P = 0.006), but there was heterogeneity among studies (heterogeneity I(2) = 70%). in studies with a low risk of bias, there was a more marked increase in diabetes odds of 10% per 5-year increase in maternal age. Adjustments for potential confounders little altered these estimates.CONCLUSIONS-There was evidence of a weak but significant linear increase in the risk of childhood type 1 diabetes across the range of maternal ages, but the magnitude of association varied between studies. A very small percentage of the increase in the incidence of childhood type 1 diabetes in recent years could be explained by increases in maternal age. Diabetes 59:486-494, 2010
Language English
Sponsor Czech Republic Ministry of Education
Department of Health of Catalonia
Department of Health of Taiwan
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Centro Internazionale Studi Diabete (Italy, Rome)
The Swedish Child Diabetes Foundation
National Health Service (NHS) National Coordinating Centre for Research Capacity Development U.K.
Research Council of Norway
German Research Foundation
Ministry for Science and Technological Development of Serbia
European Commission Health Information Strand
Diabetes U.K
Northern Ireland Department of Health and Social Services
Grant number Czech Republic Ministry of Education: MSM 0021620814
Department of Health of Taiwan: DOH 90-TD1028
FAPESP: 94/0943-0
German Research Foundation: HE 24/1-1
Ministry for Science and Technological Development of Serbia: 145084
European Commission Health Information Strand: 2007115
Date 2010-02-01
Published in Diabetes. Alexandria: Amer Diabetes Assoc, v. 59, n. 2, p. 486-494, 2010.
ISSN 0012-1797 (Sherpa/Romeo, impact factor)
Publisher Amer Diabetes Assoc
Extent 486-494
Origin http://dx.doi.org/10.2337/db09-1166
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000274435900020
URI http://repositorio.unifesp.br/handle/11600/32202

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