Etiology of childhood diarrhea in the northeast of Brazil: significant emergent diarrheal pathogens

Etiology of childhood diarrhea in the northeast of Brazil: significant emergent diarrheal pathogens

Author Ramos Moreno, Ana Carolina Google Scholar
Fernandes Filho, Antonio Google Scholar
Tardelli Gomes, Tania do Amaral Autor UNIFESP Google Scholar
Ramos, Sonia T. S. Google Scholar
Montemor, Liana P. G. Google Scholar
Tavares, Vanessa C. Google Scholar
Santos Filho, Lauro dos Google Scholar
Irino, Kinue Google Scholar
Martinez, Marina Baquerizo Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Paraiba
Adolfo Lutz Inst
Abstract In a study conducted in Joao Pessoa, northeast of Brazil, 2344 Escherichia coli isolated from 290 infants with diarrhea and 290 healthy matched controls were analyzed for virulence traits. Enteroaggregative E. coli (EAEC) was the most prevalent pathogen associated to acute diarrhea. Based on the results of colony blot hybridization, serotyping, and HEp-2 cell adherence assays, strains were separated in categories as typical enteropathogenic E. coli (EPEC) (1.7%), atypical EPEC (a-EPEC) (9.3%), EAEC (25%), enterotoxigenic E. coli (10%), and enteroinvasive E. coli (EIEC) (1.4%). No enterohemorrhagic E. coli strains were isolated. Other enteropathogens were found, including Salmonella (7.9%), Shigella spp. (4.1%), thermophilic Campylobacter spp. (2.4%), Giardia lamblia (9.3%), and Entamoeba histolytica (5.8%). All enteropathogens were associated with diarrhea (P < 0.01). However, the association was lower for EPEC and EIEC (P < 0.03). Different pathogens associated with diarrhea may have been changing in Brazil where EAEC and a-EPEC seem to be the most prevalent pathogens among them. (C) 2010 Elsevier Inc. All rights reserved.
Keywords Epidemiologic study
Diarrhea
Diarrheagenic E. coli
EAEC
Atypical EPEC
Enteropathogens
Language English
Sponsor Arlinda Marques Pediatric Hospital
Center for Tropical Medicine at the Federal University of Paraiba, Paraiba, Brazil
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2010-01-01
Published in Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 66, n. 1, p. 50-57, 2010.
ISSN 0732-8893 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 50-57
Origin http://dx.doi.org/10.1016/j.diagmicrobio.2008.03.017
Access rights Closed access
Type Article
Web of Science ID WOS:000277576800007
URI http://repositorio.unifesp.br/handle/11600/32092

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