Changes in Glucose and Glutamine Lymphocyte Metabolisms Induced by Type I Interferon alpha

Changes in Glucose and Glutamine Lymphocyte Metabolisms Induced by Type I Interferon alpha

Author Navarro, Francisco Google Scholar
Bacurau, Aline V. N. Google Scholar
Vanzelli, Andrea Google Scholar
Meneguello-Coutinho, Marcela Google Scholar
Uchida, Marco C. Google Scholar
Moraes, Milton R. Autor UNIFESP Google Scholar
Almeida, Sandro S. Autor UNIFESP Google Scholar
Wasinski, Frederick Autor UNIFESP Google Scholar
Barros, Carlos C. Autor UNIFESP Google Scholar
Wuertele, Martin Autor UNIFESP Google Scholar
Araujo, Ronaldo C. Autor UNIFESP Google Scholar
Costa Rosa, Luis F. B. Google Scholar
Bacurau, Reury Frank Pereira Google Scholar
Institution Universidade de São Paulo (USP)
Univ Fed Maranhao
Univ Prebiteriana Mackenzie
Universidade Federal de São Paulo (UNIFESP)
Abstract In lymphocytes (LY), the well-documented antiproliferative effects of IFN-alpha are associated with inhibition of protein synthesis, decreased amino acid incorporation, and cell cycle arrest. However, the effects of this cytokine on the metabolism of glucose and glutamine in these cells have not been well investigated. Thus, mesenteric and spleen LY of male Wistar rats were cultured in the presence or absence of IFN-alpha, and the changes on glucose and glutamine metabolisms were investigated. the reduced proliferation of mesenteric LY was accompanied by a reduction in glucose total consumption (35%), aerobic glucose metabolism (55%), maximal activity of glucose-6-phosphate dehydrogenase (49%), citrate synthase activity (34%), total glutamine consumption (30%), aerobic glutamine consumption (20.3%) and glutaminase activity (56%). in LY isolated from spleen, IFN alpha also reduced the proliferation and impaired metabolism. These data demonstrate that in LY, the antiproliferative effects of IFN alpha are associated with a reduction in glucose and glutamine metabolisms.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 97/3117-6
Date 2010-01-01
Published in Mediators of Inflammation. New York: Hindawi Publishing Corporation, 6 p., 2010.
ISSN 0962-9351 (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 6
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000286266700001

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