Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model

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dc.contributor.author Calcagnotto, Maria E. [UNIFESP]
dc.contributor.author Ruiz, Lorena P. [UNIFESP]
dc.contributor.author Blanco, Miriam M. [UNIFESP]
dc.contributor.author Santos-Junior, Jair G. [UNIFESP]
dc.contributor.author Valente, Maria F. [UNIFESP]
dc.contributor.author Patti, Camila [UNIFESP]
dc.contributor.author Frussa-Filho, Roberto [UNIFESP]
dc.contributor.author Santiago, Marcelo F.
dc.contributor.author Zipancic, Ivan
dc.contributor.author Alvarez-Dolado, Manuel
dc.contributor.author Mello, Luiz E. [UNIFESP]
dc.contributor.author Longo, Beatriz M. [UNIFESP]
dc.date.accessioned 2016-01-24T13:59:01Z
dc.date.available 2016-01-24T13:59:01Z
dc.date.issued 2010-01-01
dc.identifier http://dx.doi.org/10.1111/j.1528-1167.2010.02614.x
dc.identifier.citation Epilepsia. Malden: Wiley-Blackwell, v. 51, p. 71-75, 2010.
dc.identifier.issn 0013-9580
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/32028
dc.description.abstract P>Most of the gamma-aminobutyric acid (GABA)ergic interneurons in the cerebral cortex originate from restricted regions of the ventral telencephalon known as the caudal and medial ganglionic eminence (MGE) and from the preoptic area. It is well established that dysfunction of GABAergic interneurons can lead to epilepsy. During the last decade new approaches to prevent, reduce, or reverse the epileptic condition have been studied, including cell-based therapy from different sources. Recent studies have shown that transplanted neuronal precursor cells derived from MGE have the ability to migrate, differentiate into inhibitory GABAergic interneurons, and integrate into cortical and hippocampal networks, modifying the inhibitory tone in the host brain. Therefore, transplantation of neuronal precursors derived from MGE into the postnatal central nervous system (CNS) could modify the neuronal circuitry in neurologic diseases in which inhibitory synaptic function is altered, such as in epilepsy. Here, we evaluated the seizure susceptibility of mice transplanted with MGE-derived cells in the maximum electroconvulsive shock (MES) model and we review some data from different studies using GABAergic precursor or GABA-releasing cell grafts in animal models of seizure and epilepsy. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 71-75
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Epilepsia
dc.rights Acesso aberto
dc.subject Maximum electroconvulsive shock en
dc.subject Neural stem cells en
dc.subject GABAergic cells en
dc.subject Tonic seizures en
dc.subject Transplantation en
dc.title Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Ctr Andaluz Biol Mol & Med Regenerat CABIMER
dc.contributor.institution Fac Ciencias Med Santa Casa
dc.contributor.institution Universidade Federal do Rio de Janeiro (UFRJ)
dc.description.affiliation Universidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.affiliation Ctr Andaluz Biol Mol & Med Regenerat CABIMER, Dept Terapia Celular & Med Regenerat, Seville, Spain
dc.description.affiliation Fac Ciencias Med Santa Casa, Dept Ciencias Fisiol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Farmacol, São Paulo, Brazil
dc.description.affiliation Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio de Janeiro, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Farmacol, São Paulo, Brazil
dc.identifier.doi 10.1111/j.1528-1167.2010.02614.x
dc.description.source Web of Science
dc.identifier.wos WOS:000279442400014



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