Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model

Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model

Author Calcagnotto, Maria E. Autor UNIFESP Google Scholar
Ruiz, Lorena P. Autor UNIFESP Google Scholar
Blanco, Miriam M. Autor UNIFESP Google Scholar
Santos-Junior, Jair G. Autor UNIFESP Google Scholar
Valente, Maria F. Autor UNIFESP Google Scholar
Patti, Camila Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Santiago, Marcelo F. Google Scholar
Zipancic, Ivan Google Scholar
Alvarez-Dolado, Manuel Google Scholar
Mello, Luiz E. Autor UNIFESP Google Scholar
Longo, Beatriz M. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Ctr Andaluz Biol Mol & Med Regenerat CABIMER
Fac Ciencias Med Santa Casa
Universidade Federal do Rio de Janeiro (UFRJ)
Abstract P>Most of the gamma-aminobutyric acid (GABA)ergic interneurons in the cerebral cortex originate from restricted regions of the ventral telencephalon known as the caudal and medial ganglionic eminence (MGE) and from the preoptic area. It is well established that dysfunction of GABAergic interneurons can lead to epilepsy. During the last decade new approaches to prevent, reduce, or reverse the epileptic condition have been studied, including cell-based therapy from different sources. Recent studies have shown that transplanted neuronal precursor cells derived from MGE have the ability to migrate, differentiate into inhibitory GABAergic interneurons, and integrate into cortical and hippocampal networks, modifying the inhibitory tone in the host brain. Therefore, transplantation of neuronal precursors derived from MGE into the postnatal central nervous system (CNS) could modify the neuronal circuitry in neurologic diseases in which inhibitory synaptic function is altered, such as in epilepsy. Here, we evaluated the seizure susceptibility of mice transplanted with MGE-derived cells in the maximum electroconvulsive shock (MES) model and we review some data from different studies using GABAergic precursor or GABA-releasing cell grafts in animal models of seizure and epilepsy.
Keywords Maximum electroconvulsive shock
Neural stem cells
GABAergic cells
Tonic seizures
Transplantation
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2010-01-01
Published in Epilepsia. Malden: Wiley-Blackwell, v. 51, p. 71-75, 2010.
ISSN 0013-9580 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 71-75
Origin http://dx.doi.org/10.1111/j.1528-1167.2010.02614.x
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000279442400014
URI http://repositorio.unifesp.br/handle/11600/32028

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