From Galapagos to the labs: Darwinian medicine and epilepsy today

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dc.contributor.author Scorza, Fulvio A. [UNIFESP]
dc.contributor.author Cysneiros, Roberta M.
dc.contributor.author Terra, Vera C.
dc.contributor.author Arida, Ricardo M. [UNIFESP]
dc.contributor.author Scorza, Carla A. [UNIFESP]
dc.contributor.author Cavalheiro, Esper A. [UNIFESP]
dc.date.accessioned 2016-01-24T13:58:54Z
dc.date.available 2016-01-24T13:58:54Z
dc.date.issued 2009-11-01
dc.identifier http://dx.doi.org/10.1016/j.yebeh.2009.09.009
dc.identifier.citation Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 16, n. 3, p. 388-390, 2009.
dc.identifier.issn 1525-5050
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31934
dc.description.abstract In 1991, a mummy frozen in ice was found by climbers in the Tyrolean Alps. Otzi the Iceman has since been studied in the light of evolutionary explanations for diseases. This year, which marks Charles Darwin's 200th birthday and the 150th anniversary of his publication On the Origin of Species, should re-ignite discussion of the importance of the correlation between nutritional diet and diseases. Epilepsy is one of the commonest diseases in the world. Individuals with epilepsy are at higher risk of death than the general population, and Sudden unexpected death (SUDEP) is the most important direct epilepsy-related Cause of death. A number of factors may influence the risk for SUDEP. Along these lines, several studies have demonstrated that polyunsaturated (omega-3) fatty acids may reduce the risk of cardiovascular mortality, and diminish neuronal excitability. Also, omega-3 fatty acids may decrease seizure frequency, contributing to the reduction of SUDEP risk. Reconstruction of the nutritional patterns of Stone Age humans and optimal human nutrition in the present may be relevant to the prevention and treatment of chromic diseases such as epilepsy and the catastrophic evolution into epilepsy refractoriness and SUDEP. (C) 2009 Elsevier Inc. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 388-390
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Epilepsy & Behavior
dc.rights Acesso restrito
dc.subject Darwin en
dc.subject Epilepsy en
dc.subject Nutrition en
dc.subject Omega-3 fatty acids en
dc.subject Sudden unexplained death in epilepsy en
dc.title From Galapagos to the labs: Darwinian medicine and epilepsy today en
dc.type Resenha
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Presbiteriana Mackenzie
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Disciplina Neurol Expt, São Paulo, Brazil
dc.description.affiliation Univ Presbiteriana Mackenzie, Programa Posgrad Disturbios Desenvolvimento, Ctr Ciencias Biol & Saude, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Fac Med Ribeirao Preto, Ctr Cirurgia Epilepsia, Dept Neurociencias & Ciencias Comportamento, Ribeirao Preto, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Disciplina Neurol Expt, São Paulo, Brazil
dc.identifier.doi 10.1016/j.yebeh.2009.09.009
dc.description.source Web of Science
dc.identifier.wos WOS:000271935800003



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