Provocative and inhibitory effects of a video-EEG neuropsychologic protocol in juvenile myoclonic epilepsy

Provocative and inhibitory effects of a video-EEG neuropsychologic protocol in juvenile myoclonic epilepsy

Author Guaranha, Mirian Salvadori Bittar Autor UNIFESP Google Scholar
Sousa, Patricia da Silva Autor UNIFESP Google Scholar
Araujo Filho, Gerardo Maria de Autor UNIFESP Google Scholar
Lin, Katia Autor UNIFESP Google Scholar
Guilhoto, Laura Maria Figueiredo Ferreira Autor UNIFESP Google Scholar
Caboclo, Luis Otavio Sales Ferreira Autor UNIFESP Google Scholar
Yacubian, Elza Márcia Targas Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: Studies suggest that higher cognitive functions could precipitate seizures in juvenile myoclonic epilepsy (JME). the present study aimed to analyze the effects of higher mental activity on epileptiform discharges and seizures in patients with JME and compare them to those of habitual methods of activation.Methods: Seventy-six patients with JME (41 female) underwent a video-EEG (electroencephalography) neuropsychologic protocol (VNPP) and habitual methods of activation for 4-6 h.Results: Twenty-nine of the 76 (38.2%) presented provocative effect, and inhibition was seen in 28 of 31 (90.3%). A mixed effect was observed in 11 (35.5%), and 30 patients (39.5%) suffered no effect of VNPP. Action-programming tasks were more effective than thinking in provoking epileptiform discharges (23.7% and 11.0% of patients, respectively, p = 0.03). Inhibitory effect was observed equally in the various categories of tasks, except in mental calculation, which had a higher inhibitory rate. Habitual methods of activation were more effective than VNPP in provoking discharges. Anxiety disorders were diagnosed in 24 of 58 patients (41.4%); anxious patients had greater discharge indexes and no significant inhibitory effect on VNPP.Discussion: Praxis exerted the most remarkable provocative effect, in accordance with the motor circuitry hyperexcitability hypothesis in JME. Inhibitory effect, which had no such task specificity, might be mediated by a widespread cortical-thalamic pathway, possibly involving the parietal cortex. the frequent inhibitory effect found under cortical activation conditions, influenced by the presence of anxiety, supports nonpharmacologic therapeutic interventions in JME.
Keywords Idiopathic generalized epilepsy
Reflex epilepsy
Precipitant factors
Activation methods
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2009-11-01
Published in Epilepsia. Malden: Wiley-Blackwell Publishing, Inc, v. 50, n. 11, p. 2446-2455, 2009.
ISSN 0013-9580 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 2446-2455
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000271057300014

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