Role of the medial septal area on pilocarpine-induced salivary secretion and water intake

Show simple item record

dc.contributor.author Paulin, Renata Fabris
dc.contributor.author Menani, Jose V.
dc.contributor.author Colombari, Eduardo [UNIFESP]
dc.contributor.author De Paula, Patricia Maria
dc.contributor.author Almeida Colombari, Debora Simoes
dc.date.accessioned 2016-01-24T13:58:50Z
dc.date.available 2016-01-24T13:58:50Z
dc.date.issued 2009-10-28
dc.identifier http://dx.doi.org/10.1016/j.brainres.2009.08.067
dc.identifier.citation Brain Research. Amsterdam: Elsevier B.V., v. 1298, p. 145-152, 2009.
dc.identifier.issn 0006-8993
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31889
dc.description.abstract Peripheral injection of pilocarpine, a cholinergic muscarinic agonist, induces salivation, water intake and hypertension. the medial septal area (MSA) is involved in cardiovascular control and fluid-electrolyte balance. Therefore, the effects of lesions or muscarinic cholinergic blockade in the MSA on the salivation, water intake and pressor responses induced by peripheral pilocarpine (4 mu mol/kg of body weight) were investigated. Male Holtzman rats with stainless steel cannulas implanted in the MSA or submitted to electrolytic lesion of MSA were used. MSA lesion (I day) reduced the salivation (262 45 vs. sham: 501 +/- 30 mg/7 min) and water intake (2.6 +/- 0.4 vs. sham: 4 +/- 0.4 ml/1 h) induced by intraperitoneal pilocarpine, whereas 15-day MSA lesion reduced only the pilocarpine-induced water intake (2.3 +/- 0.5 ml/1 h). Pre-treatment with the muscarinic cholinergic antagonist atropine methyl bromide (4 nmol/0.5 mu l) into MSA also reduced the pilocarpine-induced salivation (420 +/- 33 mg/7 min) and water intake (1.4 +/- 0.4 ml/1 h). Conversely, MSA lesions or the blockade of muscarinic receptors in the MSA did not change the pressor response induced by intravenous pilocarpine. the results show that MSA and its muscarinic receptors are part of the forebrain circuitry activated by peripheral pilocarpine that induce salivary secretion and water intake. Moreover, they suggest that different central mechanisms are involved in the salivatory, dipsogenic and cardiovascular effects of peripheral pilocarpine in rats. (C) 2009 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 145-152
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Brain Research
dc.rights Acesso restrito
dc.subject Salivation en
dc.subject Thirst en
dc.subject Salivary gland en
dc.subject Atropine en
dc.subject Arterial pressure en
dc.subject Cholinergic receptor en
dc.title Role of the medial septal area on pilocarpine-induced salivary secretion and water intake en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution São Paulo State Univ
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation São Paulo State Univ, Fac Odontol, Dept Fisiol & Patol, UNESP,Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliation UNIFESP EPM, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnifesp UNIFESP EPM, Dept Physiol, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 06/54716-3
dc.identifier.doi 10.1016/j.brainres.2009.08.067
dc.description.source Web of Science
dc.identifier.wos WOS:000271557700014



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account