Voxel-based morphometry evaluation of patients with photosensitive juvenile myoclonic epilepsy

Voxel-based morphometry evaluation of patients with photosensitive juvenile myoclonic epilepsy

Author Lin, Katia Autor UNIFESP Google Scholar
Jackowski, Andrea Parolin Autor UNIFESP Google Scholar
Carrete Junior, Henrique Autor UNIFESP Google Scholar
Araujo Filho, Gerardo Maria de Autor UNIFESP Google Scholar
Silva, Henrique Hattori Autor UNIFESP Google Scholar
Bittar Guaranha, Mirian Salvadori Autor UNIFESP Google Scholar
Figueiredo Ferreira Guilhoto, Laura Maria Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Targas Yacubian, Elza Marcia Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract We aim to investigate structural brain abnormalities in juvenile myoclonic epilepsy (JME) patients with photosensitivity (PS). Sixty JME patients, 19 (32%) of whom were photosensitive, were submitted to 1.5 T magnetic resonance voxel-based morphometry (VBM). the control group (CTL) consisted of 30 sex-matched healthy volunteers. JME patients with (JME-PS) and without (JME-NPS) PS did not differ in their duration of disease, treatment or seizure control. VBM revealed significantly reduced bilateral gray matter volume (GMV) in thalami, insula cortices and cerebellar hemispheres; while significantly increased GMV was observed in the right superior frontal, orbitofrontal and medial. frontal gyri of the JME group compared to CTL. JME-PS had reduced bilateral GMV of visual cortices when compared with CTL; white it was not seen among JME-NPS patients. Reduced left hippocampus and left inferior frontal gyrus volume was observed among JME-PS compared with JME-NPS. This study demonstrates structural abnormalities beyond the limits of the frontal lobes and provides evidence for the role of the occipital cortex in human PS, reinforcing the existence of functional-anatomic ictogenic networks in JME and the concept of 'system epitepsies'. (C) 2009 Elsevier B.V. All rights reserved.
Keywords Magnetic resonance imaging
Voxel-based morphometry
Idiopathic generalized epilepsy
Juvenile myoclonic epilepsy
Photosensitivity
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2009-10-01
Published in Epilepsy Research. Amsterdam: Elsevier B.V., v. 86, n. 2-3, p. 138-145, 2009.
ISSN 0920-1211 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 138-145
Origin http://dx.doi.org/10.1016/j.eplepsyres.2009.05.016
Access rights Closed access
Type Article
Web of Science ID WOS:000271150600005
URI http://repositorio.unifesp.br/handle/11600/31859

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