Cross talk between kinin and angiotensin II receptors in mouse abdominal aorta

Cross talk between kinin and angiotensin II receptors in mouse abdominal aorta

Author Rodrigues, Eliete S. Autor UNIFESP Google Scholar
Martin, Renan P. Autor UNIFESP Google Scholar
Felipe, Sandra A. Autor UNIFESP Google Scholar
Bader, Michael Google Scholar
Oliveira, Suzana M. Autor UNIFESP Google Scholar
Shimuta, Suma I. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Max Delbruck Ctr Mol Med
Abstract Bradykinin (BK) is a vasorelaxant, algesic and inflammatory agent. Angiotensin II (AngII) is known to control vascular tone and promote growth, inflammation and artherogenesis. There is evidence for cross talking between BK and AngII receptors. Therefore, the effect of lack of kinin receptors was assessed in mice with genetic disruption of B(1) or B(2) and both receptors. Responsiveness of abdominal aortic rings to BK and AngII as well as the receptor gene expression of both peptides were analysed. Although no specific phenotype was displayed in the normotensive and healthy mice lacking the kinin receptors, a decreased expression level of the remaining kinin receptor mRNA was observed. AT(1) receptor mRNA level was also reduced, indicating that kinin receptors regulate AngII receptors. Downregulation of the receptors was well correlated with reduction in the reactivity of both agonists to induce contraction of aortic rings, but other signal regulations must be sought in these transgenic mice. We conclude that cross talk between kinin and AngII receptors occurs in mouse abdominal aorta and that both peptides may regulate the initiation and progression of important pathophysiological processes, such as hypertension and inflammation.
Keywords angiotensin II
cross talk
kinin receptor-deficient mice
Language English
Sponsor Fundacao de Amparo a Pesquisa, do Estado de São Paulo
Coordernacao de Aperfeicoamento de Pessoal de Nivel Superior
Grant number Fundacao de Amparo a Pesquisa, do Estado de São Paulo: 2007/03370-2
Date 2009-09-01
Published in Biological Chemistry. Berlin: Walter de Gruyter & Co, v. 390, n. 9, p. 907-913, 2009.
ISSN 1431-6730 (Sherpa/Romeo, impact factor)
Publisher Walter de Gruyter & Co
Extent 907-913
Access rights Closed access
Type Article
Web of Science ID WOS:000269485600009

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