In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii

In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii

Author Cordeiro, Rossana de Aguiar Google Scholar
Nogueira Brilhante, Raimunda Samia Google Scholar
Gadelha Rocha, Marcos Fabio Google Scholar
Astete Medrano, Delia Jessica Google Scholar
Monteiro, Andre Jalles Google Scholar
Tavares, Juliane Lira Google Scholar
Chaves de Lima, Rita Amanda Google Scholar
Camargo, Zoilo Pires de Autor UNIFESP Google Scholar
Costa Sidrim, Jose Julio Google Scholar
Institution Univ Fed Ceara
Univ Estadual Ceara
Universidade Federal de São Paulo (UNIFESP)
Abstract The aim of the present study was to evaluate the in vitro interactions of antituberculous drugs (ATDs) with antifungals against Coccidioides posadasii. Eighteen drug combinations, formed by an ATD (isoniazid, pyrazinamide or ethambutol) plus an antifungal (amphotericin B, ketoconazole, itraconazole, fluconazole, voriconazole or caspofungin), were tested using the checkerboard method. All the antimicrobial combinations inhibited C. posadasii strains and synergistic interactions were observed for 10 combinations. Antagonism between the tested drugs was not observed. Stronger synergistic interactions were seen in the combinations formed by triazoles plus ethambutol as well as itraconazole plus pyrazinamide. Further studies in animal models are needed to confirm the usefulness of these combinations. (C) 2009 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.
Keywords Coccidioides posadasii
Antituberculous drugs
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number CNPq: 620160/2008-0
FAPESP: 4/14270-0
Date 2009-09-01
Published in International Journal of Antimicrobial Agents. Amsterdam: Elsevier B.V., v. 34, n. 3, p. 278-280, 2009.
ISSN 0924-8579 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 278-280
Access rights Closed access
Type Article
Web of Science ID WOS:000269273200018

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