Prognostic factors and outcomes for osteosarcoma: An international collaboration

Prognostic factors and outcomes for osteosarcoma: An international collaboration

Author Pakos, Emilios E. Google Scholar
Nearchou, Andreas D. Google Scholar
Grimer, Robert J. Google Scholar
Koumoullis, Haris D. Google Scholar
Abudu, Adesegun Google Scholar
Bramer, Jos A. M. Google Scholar
Jeys, Lee M. Google Scholar
Franchi, Alessandro Google Scholar
Scoccianti, Guido Google Scholar
Campanacci, Domenico Google Scholar
Capanna, Rodolfio Google Scholar
Aparicio, Jorge Google Scholar
Tabone, Marie-Dominique Google Scholar
Holzer, Gerold Google Scholar
Abdolvahab, Fashid Google Scholar
Funovics, Philipp Google Scholar
Dominkus, Martin Google Scholar
Ilhan, Inci Google Scholar
Berrak, Su G. Google Scholar
Patino-Garcia, Ana Google Scholar
Sierrasesumaga, Luis Google Scholar
San-Julian, Mikel Google Scholar
Garraus, Moira Google Scholar
Petrili, Antonio Sergio Autor UNIFESP Google Scholar
Garcia Filho, Reynaldo Jesus Autor UNIFESP Google Scholar
Pacheco Donato Macedo, Carla Renata Autor UNIFESP Google Scholar
Seixas Alves, Maria Teresa de Autor UNIFESP Google Scholar
Seiwerth, Sven Google Scholar
Nagarajan, Rajaram Google Scholar
Cripe, Timothy P. Google Scholar
Ioannidis, John P. A. Google Scholar
Institution Univ Ioannina
Royal Orthopaed Hosp
Univ Florence
Hosp Univ La Fe
Hop Enfants Armand Trousseau
Med Univ Vienna
Ankara Oncol Hosp
Marmara Univ
Univ Navarra
Univ Navarra Clin
Universidade Federal de São Paulo (UNIFESP)
Med Fac Zagreb
Cincinnati Childrens Hosp
Tufts Univ
Abstract We aimed to evaluate the prognostic significance of traditional clinical predictors in osteosarcoma through an international collaboration of 10 teams of investigators (2680 patients) who participated. in multivariate models the mortality risk increased with older age, presence of metastatic disease at diagnosis, development of local recurrence when the patient was first seen, use of amputation instead of limb salvage/wide resection, employment of unusual treatments, use of chemotherapeutic regimens other than anthracycline and platinum and use of methotrexate. it was also influenced by the site of the tumour. the risk of metastasis increased when metastatic disease was present at the time the patient was first seen and also increased with use of amputation or unusual treatment combinations or chemotherapy regimens not including anthracycline and platinum. Local recurrence risk was higher in older patients, in those who had local recurrence when first seen and when no anthracycline and platinum were used in chemotherapy. Results were similar when limited to patients seen after 1990 and treated with surgery plus combination chemotherapy. This large-scale international collaboration identifies strong predictors of major clinical outcomes in osteosarcoma. (C) 2009 Published by Elsevier B.V.
Keywords Osteosarcoma
Clinical predictors
International collaboration
Language English
Date 2009-09-01
Published in European Journal of Cancer. Oxford: Elsevier B.V., v. 45, n. 13, p. 2367-2375, 2009.
ISSN 0959-8049 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 2367-2375
Access rights Closed access
Type Article
Web of Science ID WOS:000270645700026

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