Relationship between bone mineral density, leptin and insulin concentration in Brazilian obese adolescents

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dc.contributor.author Prado, Wagner Luiz do
dc.contributor.author Piano, Aline de [UNIFESP]
dc.contributor.author Lazaretti-Castro, Marise [UNIFESP]
dc.contributor.author Mello, Marco Tulio de [UNIFESP]
dc.contributor.author Stella, Sergio Garcia
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Oller do Nascimento, Claudia Maria [UNIFESP]
dc.contributor.author Oyama, Lila Missae [UNIFESP]
dc.contributor.author Lofrano, Mara Cristina [UNIFESP]
dc.contributor.author Tock, Lian [UNIFESP]
dc.contributor.author Caranti, Danielle Arisa [UNIFESP]
dc.contributor.author Damaso, Ana Raimunda [UNIFESP]
dc.date.accessioned 2016-01-24T13:58:39Z
dc.date.available 2016-01-24T13:58:39Z
dc.date.issued 2009-09-01
dc.identifier http://dx.doi.org/10.1007/s00774-009-0082-6
dc.identifier.citation Journal of Bone and Mineral Metabolism. Tokyo: Springer Tokyo, v. 27, n. 5, p. 613-619, 2009.
dc.identifier.issn 0914-8779
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31767
dc.description.abstract Despite the epidemic of adolescent obesity, the effect of obesity and hormones on bone mineral accrual during growth is poorly understood. Studies using dual-energy X-ray to examine the effect of obesity on bone mass in children and adolescents have yielded conflicting results. the aim of this study was to explore the combined and independent contributions of body mass index, body composition, leptin, insulin, glucose levels and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) to bone mineral density (BMD) and bone mineral content in a group of Brazilian obese adolescents. This study included 109 post-pubescent obese adolescents. A whole-body dual-energy X-ray absorptiometry scan was performed,using a HOLOGIC QDR4200, to determine whole-body BMD and body composition. Blood samples were collected in the outpatient clinic after an overnight fast, and evaluated for fasting blood glucose and immunoreactive insulin. Leptin levels were assessed with a radioimmunoassay kit. Insulin resistance was assessed by HOMA-IR and the quantitative insulin sensitivity check index. Our results showed that insulin levels and HOMA-IR correlated negatively with BMD and a linear regression analysis showed that serum leptin is inversely associated to BMD adjusted for body mass. in conclusion, our data support the hypothesis that leptin, insulin and HOMA-IR are inversely associated with BMD and play a significant direct role in bone metabolism. en
dc.description.sponsorship CENESP
dc.description.sponsorship FADA
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship CEPID/Sleep
dc.description.sponsorship UNIFESP
dc.format.extent 613-619
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Journal of Bone and Mineral Metabolism
dc.rights Acesso restrito
dc.subject Obesity en
dc.subject Bone mass en
dc.subject Hormones en
dc.subject DEXA en
dc.subject Body composition en
dc.title Relationship between bone mineral density, leptin and insulin concentration in Brazilian obese adolescents en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Pernambuco
dc.contributor.institution Univ Ribeirao Preto UNAERP
dc.description.affiliation Universidade Federal de São Paulo, Nutr Postgrad Program, Paulista Med Sch, BR-04020060 São Paulo, Brazil
dc.description.affiliation Univ Pernambuco, Phys Educ High Sch, Recife, PE, Brazil
dc.description.affiliation Univ Ribeirao Preto UNAERP, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychobiol, Paulista Med Sch, BR-04020060 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biosci, Paulista Med Sch, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Nutr Postgrad Program, Paulista Med Sch, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychobiol, Paulista Med Sch, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biosci, Paulista Med Sch, BR-04020060 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2006/00684-3
dc.description.sponsorshipID FAPESP: 2008/53069-0
dc.description.sponsorshipID CEPID/Sleep: 9814303-3 st
dc.identifier.doi 10.1007/s00774-009-0082-6
dc.description.source Web of Science
dc.identifier.wos WOS:000268951300013



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