Relationship between bone mineral density, leptin and insulin concentration in Brazilian obese adolescents

Relationship between bone mineral density, leptin and insulin concentration in Brazilian obese adolescents

Author Prado, Wagner Luiz do Google Scholar
Piano, Aline de Autor UNIFESP Google Scholar
Lazaretti-Castro, Marise Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Stella, Sergio Garcia Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Oller do Nascimento, Claudia Maria Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Lofrano, Mara Cristina Autor UNIFESP Google Scholar
Tock, Lian Autor UNIFESP Google Scholar
Caranti, Danielle Arisa Autor UNIFESP Google Scholar
Damaso, Ana Raimunda Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Pernambuco
Univ Ribeirao Preto UNAERP
Abstract Despite the epidemic of adolescent obesity, the effect of obesity and hormones on bone mineral accrual during growth is poorly understood. Studies using dual-energy X-ray to examine the effect of obesity on bone mass in children and adolescents have yielded conflicting results. the aim of this study was to explore the combined and independent contributions of body mass index, body composition, leptin, insulin, glucose levels and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) to bone mineral density (BMD) and bone mineral content in a group of Brazilian obese adolescents. This study included 109 post-pubescent obese adolescents. A whole-body dual-energy X-ray absorptiometry scan was performed,using a HOLOGIC QDR4200, to determine whole-body BMD and body composition. Blood samples were collected in the outpatient clinic after an overnight fast, and evaluated for fasting blood glucose and immunoreactive insulin. Leptin levels were assessed with a radioimmunoassay kit. Insulin resistance was assessed by HOMA-IR and the quantitative insulin sensitivity check index. Our results showed that insulin levels and HOMA-IR correlated negatively with BMD and a linear regression analysis showed that serum leptin is inversely associated to BMD adjusted for body mass. in conclusion, our data support the hypothesis that leptin, insulin and HOMA-IR are inversely associated with BMD and play a significant direct role in bone metabolism.
Keywords Obesity
Bone mass
Body composition
Language English
Sponsor CENESP
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2006/00684-3
FAPESP: 2008/53069-0
CEPID/Sleep: 9814303-3 st
Date 2009-09-01
Published in Journal of Bone and Mineral Metabolism. Tokyo: Springer Tokyo, v. 27, n. 5, p. 613-619, 2009.
ISSN 0914-8779 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 613-619
Access rights Closed access
Type Article
Web of Science ID WOS:000268951300013

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