cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis

cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis

Autor Gatti, Luciano Lobo Autor UNIFESP Google Scholar
Lábio, Roger Willian de Google Scholar
Silva, Luiz Carlos da Google Scholar
Smith, Marilia de Arruda Cardoso Autor UNIFESP Google Scholar
Payão, Spencer Luiz Marques Autor UNIFESP Google Scholar
Instituição School of Medicine of Marília Department of Genetic and Molecular Biology Hemocentro
Universidade Federal de São Paulo (UNIFESP)
FAMEMA Department of Pathology
Resumo Helicobacter pylori is a spiral-shaped Gram-negative bacterium. It colonizes the gastric mucosa of humans and persists for decades if not treated. Helicobacter pylori infection affects more than half of the world's population and invariably results in chronic gastritis. The cagA gene is present in about 60 to 70% of H. pylori strains; it encodes a high-molecular-weight protein (120 to 140 kDa) and several investigators have noted a correlation between strains that possess cagA and the severity of gastric mucosal inflammation. We examined the relation between cagA status in H. pylori strains and chronic gastritis with inflammatory processes in children from Marília, São Paulo, Brazil. One-hundred-twenty-one children were analyzed histopathologically and by polymerase chain reaction (PCR) to detect H. pylori and cagA. We then looked for an association between cagA presence and inflammatory infiltration. Using histology and PCR, we found 47% H. pylori positive infection; 29 children were diagnosed with chronic gastritis, while 28 showed normal mucosa by histopathological analysis. CagA presence was genotyped in both groups, and an inflammatory infiltrate was studied in all infected children with chronic gastritis. We found cagA strains in 20 of 29 (69%) children with chronic gastritis and 18 of 28 (64%) with normal mucosa, demonstrating a strong relationship between the strains and the inflammatory process. We found a positive association between an inflammatory process associated with H. pylori of cagA+ strains and chronic gastritis development.
Palavra-chave Helicobacter pylori infection
cagA
inflammatory infiltrate
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data de publicação 2006-08-01
Publicado em Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 10, n. 4, p. 254-258, 2006.
ISSN 1413-8670 (Sherpa/Romeo)
Publicador Brazilian Society of Infectious Diseases
Extensão 254-258
Fonte http://dx.doi.org/10.1590/S1413-86702006000400008
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1413-86702006000400008 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/3174

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