The ineffectiveness of fibrin glue and cyanoacrylate on fixation of meniscus transplants in rabbits

The ineffectiveness of fibrin glue and cyanoacrylate on fixation of meniscus transplants in rabbits

Author Reckers, Leandro Jose Google Scholar
Fagundes, Djalma José Autor UNIFESP Google Scholar
Cohen, Moises Autor UNIFESP Google Scholar
Institution Pelotas Catholic Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract Our aim was to evaluate whether a fibrin glue and octyl-cyanoacrylate can promote fixation of meniscal allograft in rabbits. the medial menisci of 18 rabbits were frozen and stored at - 73 degrees C (30 days) and then was allotransplantation and fixed by: GSu (n=6) soft tissue; GFi (n=6) fibrin glue; GCy (n=6) cyanoacrylate. They were evaluated by daily surgery recovery score (4 weeks), gross inspection and cells density on scaffold. A severe inflammatory response with caseous necrosis from the inside of the joint on through the approach incision led us to an early sacrifice (16th day) of all animals of GCy. the daily score of recovery was similar in both groups GSu and GFi, with a peak of 40% of mild Suffering score in the 12th day. At the 4th week in all animals of GFi the menisci were loose into the joint and the density of cells of collagen matrix was significantly fewer (p<0.001) than the GSu. the octyl-cyanoacrylate adhesive was totally inadequate for use on fixation of an allograft implant due to the severe inflammatory response. the fibrin glue was inappropriate to promote the allograft fixation and subsequently impaired the cells spread into the collagen matrix of allograft implant. (C) 2008 Elsevier B.V. All rights reserved.
Keywords Meniscus
Allograft
Transplantation
Fibrin glue
Cyanoacrylate
Rabbits
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Coordenacao de Pessoal de Nivel Superior
Ministry of Education, Brazil
Date 2009-08-01
Published in Knee. Amsterdam: Elsevier B.V., v. 16, n. 4, p. 290-294, 2009.
ISSN 0968-0160 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 290-294
Origin http://dx.doi.org/10.1016/j.knee.2008.12.009
Access rights Closed access
Type Article
Web of Science ID WOS:000267776800012
URI http://repositorio.unifesp.br/handle/11600/31722

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