Carnitine reduces testicular damage in rats treated with etoposide in the prepubertal phase

Carnitine reduces testicular damage in rats treated with etoposide in the prepubertal phase

Author Okada, Fatima Kazue Autor UNIFESP Google Scholar
Stumpp, Taiza Autor UNIFESP Google Scholar
Miraglia, Sandra Maria Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Etoposide is a chemotherapeutic agent that induces cell death by blocking topoisomerase II catalytic function. Although etoposide is effective in the treatment of cancer, it also causes the death of normal proliferating cells, including male germ cells. Administration of etoposide during the prepubertal phase causes diturbances in several testicular morphometric parameters and in Sertoli cells. Cytoprotection of the seminiferous epithelium is the only means of preserving potential male reproduction in prepubertal cancer patients. Carnitine, an amino acid naturally present in normal cells, is a promising cryoprotectant as it is concentrated in the epididymis and promotes sperm maturation. We have therefore investigated whether carnitine protects rat testes against etoposide and, thus, improves fertility in adulthood. Our results suggest that carnitine partially protects the testis against damage caused by etoposide, although the mechanism by which it happens remains unknown.
Keywords Carnitine
Etoposide
Apoptosis
Spermatogenesis
Testis
Rat (Wistar)
Language English
Date 2009-08-01
Published in Cell and Tissue Research. New York: Springer, v. 337, n. 2, p. 269-280, 2009.
ISSN 0302-766X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 269-280
Origin http://dx.doi.org/10.1007/s00441-009-0801-2
Access rights Closed access
Type Article
Web of Science ID WOS:000268422800008
URI http://repositorio.unifesp.br/handle/11600/31704

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