Amphetamine- and nicotine-induced cross-sensitization in adolescent rats persists until adulthood

Amphetamine- and nicotine-induced cross-sensitization in adolescent rats persists until adulthood

Author Santos, Gabriela C. Autor UNIFESP Google Scholar
Marin, Marcelo T. Autor UNIFESP Google Scholar
Cruz, Fabio C. Autor UNIFESP Google Scholar
DeLucia, Roberto Google Scholar
Planeta, Cleopatra S. Autor UNIFESP Google Scholar
Institution UNESP São Paulo State Univ
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Nicotine and psychostimulants are often abused in combination and drug abuse often begins during adolescence and can have long-term consequences. Behavioral sensitization has been suggested as an animal model of neuroplasticity implicated in the development of drug addiction. We evaluated whether the pretreatment with nicotine (0.4 mg/kg; s.c.) or amphetamine (5.0 mg/kg: i.p.) in adolescent rats [from postnatal day (P) 28 to P34] could induce cross-sensitization to nicotine and amphetamine when animals were challenged during both adolescence (P37) and adulthood (P70), in separate groups of animals. Adolescent animals pretreated with amphetamine displayed behavioral sensitization to nicotine. which persisted until adulthood. Moreover. adolescent animals pretreated with nicotine showed sensitized locomotor response to amphetamine in the adulthood. These data suggest that adolescents who abuse nicotine may be particularly susceptible to the effects of amphetamine and vice versa. Moreover. this increased vulnerability may persist through their development until adulthood.
Keywords Adolescence
amphetamine
behavioral sensitization
drug addiction
locomotion
nicotine
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estaclo de São Paulo
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number Fundacao de Amparo a Pesquisa do Estaclo de São Paulo: FAPESP-97/11010-2
Date 2009-07-01
Published in Addiction Biology. Malden: Wiley-Blackwell Publishing, Inc, v. 14, n. 3, p. 270-275, 2009.
ISSN 1355-6215 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 270-275
Origin http://dx.doi.org/10.1111/j.1369-1600.2009.00153.x
Access rights Closed access
Type Article
Web of Science ID WOS:000268180100004
URI http://repositorio.unifesp.br/handle/11600/31666

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