Could sudden death syndrome (SDS) in chickens (Gallus gallus) be a valid animal model for sudden unexpected death in epilepsy (SUDEP)?

Could sudden death syndrome (SDS) in chickens (Gallus gallus) be a valid animal model for sudden unexpected death in epilepsy (SUDEP)?

Author Scorza, F. A. Autor UNIFESP Google Scholar
Albuquerque, R. de Google Scholar
Arida, R. M. Autor UNIFESP Google Scholar
Schmidt, B. Autor UNIFESP Google Scholar
Almeida, Antonio-Carlos G. de Google Scholar
Scorza, Carla A. Autor UNIFESP Google Scholar
Cavalheiro, E. A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Fed Sao Joao Rei
Abstract Epilepsy is the most common serious neurological disorder and approximately 1% of the population worldwide has epilepsy. Moreover, sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Information concerning fisk factors for SUDEP is conflicting, but potential risk factors include: young age, early onset of epilepsy, duration of epilepsy, uncontrolled seizures, seizure frequency, AED number and winter temperatures. Additionally, the cause of SUDEP is still unknown; however, the most commonly suggested mechanisms are cardiac abnormalities during and between seizures. Similarly, sudden death syndrome (SDS) is a disease characterized by an acute death of well-nourished and seeming healthy Gallus gallus after abrupt and brief flapping of their wings and incidence of SDS these animals has recently increased worldwide. Moreover, the exactly cause of SDS in Gallus gallus is unknown, but is very probable that cardiac abnormalities play a potential role. Due the similarities between SUDEP and SDS and as Gallus gallus behavioral manifestation during SDS phenomenon is close of a tonic-clonic seizure, in this paper we suggest that epilepsy could be a new possible causal factor for SDS. (C) 2009 Elsevier B.V. All rights reserved.
Language English
Date 2009-07-01
Published in Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 73, n. 1, p. 67-69, 2009.
ISSN 0306-9877 (Sherpa/Romeo, impact factor)
Publisher Churchill Livingstone
Extent 67-69
Origin http://dx.doi.org/10.1016/j.mehy.2008.10.035
Access rights Closed access
Type Article
Web of Science ID WOS:000266579100021
URI http://repositorio.unifesp.br/handle/11600/31644

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