A Neuropsychological Study Comparing Patients Infected With HCV and HBV Without Psychiatric Comorbidities

A Neuropsychological Study Comparing Patients Infected With HCV and HBV Without Psychiatric Comorbidities

Author Quarantini, Lucas C. Autor UNIFESP Google Scholar
Miranda-Scippa, Angela Google Scholar
Batista-Neves, Susana Google Scholar
Powell, Vania B. Google Scholar
Abreu, Neander Google Scholar
Abreu, Katiusha C. Google Scholar
Moura, Ilka Google Scholar
Crane, Jacquelyn Google Scholar
Sampaio, Aline S. Google Scholar
Netto, Liana. R. Google Scholar
deOliveira, Irismar R. Google Scholar
Parana, Raymundo Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Lacerda, Acioly L. T. . Autor UNIFESP Google Scholar
Institution Universidade Federal da Bahia (UFBA)
Universidade Federal de São Paulo (UNIFESP)
Harvard Univ
Universidade de São Paulo (USP)
Inst Sinapse Neurociencias Clin
Ctr Pesquisa & Ensaios Clin Sinapse Bairral
Abstract Hepatitis C is one of the most common chronic infectious diseases worldwide, with well-documented extra-hepatic manifestations, such as a broad number of cognitive deficits. These impairments may be explained by psychiatric comorbidities, which have not been investigated properly in the literature. in order to elucidate a specific hepatitis C virus (HCV) induced cognitive impairment not related to mental disorders, neuropsychological performance of patients infected with HCV was compared with that of patients infected with hepatitis B virus cognitive impairment, especially psychiatric comorbidities. A total of 33 patients infected with HCV and 22 patients infected with HBV were included in the study. There were no significant differences between the two groups with regard to age or years of education. the group of patients infected with HCV performed significantly worse on visuo-spatial memory tasks after adjusting for years of education and age. There were no significant differences between patients infected with HCV and patients infected with HBV with regards to other neuropsychological functions. the data indicate that patients infected with HCV patients have poorer visuo-spacial memory performance than patients infected with HBV, suggesting that the cognitive deficit may be specific to HCV infection and not to secondary comorbid psychiatric disorders. J. Med. Virol. 81: 1184-1188, 2009. (C) 2009 Wiley-Liss, Inc.
Keywords hepatitis C virus
cognitive dysfunction
chronic liver disease
mental disorders
major depression
Language English
Sponsor FAPESB
Grant number FAPESB: 195712163383
Date 2009-07-01
Published in Journal of Medical Virology. Hoboken: Wiley-liss, v. 81, n. 7, p. 1184-1188, 2009.
ISSN 0146-6615 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1184-1188
Origin http://dx.doi.org/10.1002/jmv.21508
Access rights Closed access
Type Article
Web of Science ID WOS:000266613900008
URI http://repositorio.unifesp.br/handle/11600/31628

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