Polyploidy in atypical grade II choroid plexus papilloma of the posterior fossa

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dc.contributor.author Brassesco, Maria Sol
dc.contributor.author Valera, Elvis Terci
dc.contributor.author Neder, Luciano
dc.contributor.author Castro-Gamero, Angel Mauricio
dc.contributor.author Arruda, Darlene
dc.contributor.author Machado, Helio Rubens
dc.contributor.author Sakamoto-Hojo, Elza Tiemi
dc.contributor.author Tone, Luiz Gonzaga
dc.date.accessioned 2016-01-24T13:52:37Z
dc.date.available 2016-01-24T13:52:37Z
dc.date.issued 2009-06-01
dc.identifier http://dx.doi.org/10.1111/j.1440-1789.2008.00949.x
dc.identifier.citation Neuropathology. Malden: Wiley-Blackwell Publishing, Inc, v. 29, n. 3, p. 293-298, 2009.
dc.identifier.issn 0919-6544
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31589
dc.description.abstract Cytogenetic studies of choroid plexus tumors, particularly for atypical choroid plexus papillomas, have been rarely described. in the present report, the cytogenetic investigation of an atypical choroid plexus papilloma occurring at the posterior fossa of a 16-year-old male is described. Comparative genome hybridization analysis demonstrated gains of genetic material from almost all chromosomes. Chromosome losses involved 19p, regional losses at chromosome X and loss of chromosome Y. the presence of polyploid cells was confirmed by fluorescence in situ hybridization analysis with probes directed to centromeric regions. Furthermore, the microscopic analysis of cultures showed nuclear buds, nucleoplasmic bridges, and micronuclei in 23% of tumor cells suggesting the presence of complex chromosomal abnormalities. Previous cytogenetic studies on choroid plexus papillomas showed either normal, hypodiploid or hyperdiploid karyotypes. To the best of our knowledge, this is the first report of polyploidy in choroid plexus papilloma of intermediate malignancy grade. Although the mechanisms beneath such genome duplication remain to be elucidated, the observed abnormal nuclear shapes indicate constant restructuring of the tumor's genome and deserves further investigation. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 293-298
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Neuropathology
dc.rights Acesso restrito
dc.subject atypical choroid plexus papilloma en
dc.subject CGH en
dc.subject children en
dc.subject cytogenetics en
dc.subject polyploidy en
dc.title Polyploidy in atypical grade II choroid plexus papilloma of the posterior fossa en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Univ São Paulo, Fac Med Ribeirao Preto, Dept Pediat, Div Pediat Oncol, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Fac Med Ribeirao Preto, Dept Pathol, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Fac Med Ribeirao Preto, Dept Genet, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Fac Med Ribeirao Preto, Dept Surg & Anat, Div Neurosurg, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Fac Philosophy Sci & Letters, Dept Biol, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 07/54236-4
dc.description.sponsorshipID FAPESP: 06/04827-3
dc.identifier.doi 10.1111/j.1440-1789.2008.00949.x
dc.description.source Web of Science
dc.identifier.wos WOS:000266072900011



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