Polyploidy in atypical grade II choroid plexus papilloma of the posterior fossa

Polyploidy in atypical grade II choroid plexus papilloma of the posterior fossa

Author Brassesco, Maria Sol Google Scholar
Valera, Elvis Terci Google Scholar
Neder, Luciano Google Scholar
Castro-Gamero, Angel Mauricio Google Scholar
Arruda, Darlene Google Scholar
Machado, Helio Rubens Google Scholar
Sakamoto-Hojo, Elza Tiemi Google Scholar
Tone, Luiz Gonzaga Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Cytogenetic studies of choroid plexus tumors, particularly for atypical choroid plexus papillomas, have been rarely described. in the present report, the cytogenetic investigation of an atypical choroid plexus papilloma occurring at the posterior fossa of a 16-year-old male is described. Comparative genome hybridization analysis demonstrated gains of genetic material from almost all chromosomes. Chromosome losses involved 19p, regional losses at chromosome X and loss of chromosome Y. the presence of polyploid cells was confirmed by fluorescence in situ hybridization analysis with probes directed to centromeric regions. Furthermore, the microscopic analysis of cultures showed nuclear buds, nucleoplasmic bridges, and micronuclei in 23% of tumor cells suggesting the presence of complex chromosomal abnormalities. Previous cytogenetic studies on choroid plexus papillomas showed either normal, hypodiploid or hyperdiploid karyotypes. To the best of our knowledge, this is the first report of polyploidy in choroid plexus papilloma of intermediate malignancy grade. Although the mechanisms beneath such genome duplication remain to be elucidated, the observed abnormal nuclear shapes indicate constant restructuring of the tumor's genome and deserves further investigation.
Keywords atypical choroid plexus papilloma
CGH
children
cytogenetics
polyploidy
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 07/54236-4
FAPESP: 06/04827-3
Date 2009-06-01
Published in Neuropathology. Malden: Wiley-Blackwell Publishing, Inc, v. 29, n. 3, p. 293-298, 2009.
ISSN 0919-6544 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 293-298
Origin http://dx.doi.org/10.1111/j.1440-1789.2008.00949.x
Access rights Closed access
Type Article
Web of Science ID WOS:000266072900011
URI http://repositorio.unifesp.br/handle/11600/31589

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