Risk factors for poor immune response to influenza vaccination in elderly people

Risk factors for poor immune response to influenza vaccination in elderly people

Autor Bellei, Nancy Cristina Junqueira Autor UNIFESP Google Scholar
Carraro, Emerson Autor UNIFESP Google Scholar
Castelo Filho, Adauto Autor UNIFESP Google Scholar
Granato, Celso Francisco Hernandes Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Influenza vaccination of elderly people is efficacious and cost effective for the prevention of influenza and its complications. Some studies have pointed out low immunogenicity in this group. Health status has been poorly investigated as a risk factor that may influence the immune response to influenza vaccine. We established an immunization response study of a highly-matched elderly population in a nursing home. One-hundred-twenty subjects of Ashkenazian origin had their vaccine-induced antibody response assessed. Good response was obtained in 30.8% (37/120), and 31.7% (38/120) did not react. A lack of good response was found to be associated with dementia (P=0.016) in a multivariate analysis. In addition to dementia, malnutrition was frequently observed among poor responders, suggesting that these factors should be considered in vaccination studies. Chemoprophylaxis in addition to vaccination for elderly presenting dementia should be considered, particularly for those people living nursing homes.
Palavra-chave Influenza
vaccination
immune response
risk factors
dementia
Idioma Inglês
Data de publicação 2006-08-01
Publicado em Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 10, n. 4, p. 269-273, 2006.
ISSN 1413-8670 (Sherpa/Romeo)
Publicador Brazilian Society of Infectious Diseases
Extensão 269-273
Fonte http://dx.doi.org/10.1590/S1413-86702006000400011
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1413-86702006000400011 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/3158

Exibir registro completo




Arquivo

Nome: S1413-86702006000400011.pdf
Tamanho: 48.96KB
Formato: PDF
Descrição:
Abrir arquivo

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta