Central and peripheral corneal thickness measured with optical coherence tomography, Scheimpflug imaging, and ultrasound pachymetry in normal, keratoconus-suspect, and post-laser in situ keratomileusis eyes

Central and peripheral corneal thickness measured with optical coherence tomography, Scheimpflug imaging, and ultrasound pachymetry in normal, keratoconus-suspect, and post-laser in situ keratomileusis eyes

Author Prospero Ponce, Claudia Maria Google Scholar
Rocha, Karolinne Maia Autor UNIFESP Google Scholar
Smith, Scott D. Google Scholar
Krueger, Ronald R. Google Scholar
Institution Cleveland Clin
Sch Med
Universidade Federal de São Paulo (UNIFESP)
Abstract PURPOSE: To compare central (CCT) and peripheral corneal thickness (PCT) using Scheimpflug imaging (Pentacam), high-speed optical coherence tomography (Visante OCT), and ultrasound (US) pachymetry (Sonogage Corneo-Gage Plus) in normal, keratoconus-suspect, and post-laser in situ keratomileusis (LASIK) eyes.SETTING: Department of Refractive Surgery, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.METHODS: the CCT and PCT were retrospectively measured using US pachymetry, Scheimpflug imaging, and high-speed OCT from January 2006 to March 2008. the influence of age and absolute magnitude of corneal thickness were also analyzed. Analysis was by multivariate generalized estimating equations, multivariate linear regression, and linear regression plots.RESULTS: One hundred sixty-three eyes were analyzed. Ultrasound pachymetry CCT measurements were consistently higher than Scheimpflug and OCT measurements (mean difference 6.5 mu m +/- 1.8 [SD] and 7.5 +/- 1.4 mu m, respectively) (both P<.0005) in normal eyes; the difference was statistically similar and not greater with keratoconus suspicion, age, or absolute magnitude of corneal thickness (P>.05). Scheimpflug measurements were significantly lower than US pachymetry in post-LASIK eyes (P<.0005). There was no statistically significant difference (mean 0.9 +/- 1.4 mu m) in Scheimpflug and OCT CCT measurements (P>.5), although Scheimpflug measurements were significantly lower in post-LASIK eyes (P<.0005). Scheimpflug PCT measurements were higher than OCT measurements, showing more agreement with increasing age (P = .017).CONCLUSIONS: Scheimpflug and OCT CCT measurements were reproducible but always thinner than US pachymetry in normal and keratoconus-suspect eyes. in post-LASIK eyes, OCT pachymetry maps were more accurate than Scheimpflug maps. the influence of age on PCT requires further study.
Language English
Date 2009-06-01
Published in Journal of Cataract and Refractive Surgery. New York: Elsevier B.V., v. 35, n. 6, p. 1055-1062, 2009.
ISSN 0886-3350 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1055-1062
Origin http://dx.doi.org/10.1016/j.jcrs.2009.01.022
Access rights Closed access
Type Article
Web of Science ID WOS:000266797900028
URI http://repositorio.unifesp.br/handle/11600/31569

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