Effects of calcium supplementation on body weight reduction in overweight calcium stone formers

Effects of calcium supplementation on body weight reduction in overweight calcium stone formers

Author Menon, Viviane Barcellos Autor UNIFESP Google Scholar
Baxmann, Alessandra Calabria Autor UNIFESP Google Scholar
Froeder, Leila Autor UNIFESP Google Scholar
Martini, Ligia Araujo Google Scholar
Heilberg, Ita Pfeferman Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract A randomized, placebo-controlled trial was conducted in overweight calcium stone-forming (CSF) patients, to evaluate the effect of calcium supplementation associated with a calorie-restricted diet on body weight (BW) and fat reduction and its potential changes upon serum and urinary parameters. Fifteen patients were placed on a hypocaloric diet for 3 months, supplemented with either calcium carbonate (CaCO(3), n = 8) or placebo (n = 7), 500 mg bid. Blood and 24-h urine samples were collected and body composition was assessed at baseline and after the intervention. At the end of the study, final BW was significantly lower vs baseline in both CaCO(3) (74 +/- A 14 vs. 80 +/- A 14 kg, P = 0.01) and placebo groups (80 +/- A 10 vs. 87 +/- A 9 kg, P = 0.02) but the mean percentage of loss of body weight and body fat did not differ between CaCO(3) and placebo (7.0 +/- A 2.0 vs. 8.0 +/- A 3.0%, P = 0.40 and 13.0 +/- A 7.0 vs. 13.0 +/- A 10.0%; P = 0.81, respectively). After CaCO(3) or placebo, no significant differences versus baseline were observed for urinary parameters in both CaCO(3) and placebo, except for a higher mean urinary citrate in placebo group. These data suggest that increasing calcium intake by calcium carbonate supplementation did not contribute to a further reduction of BW and fat in overweight CSF patients submitted to a hypocaloric diet nor altered urinary lithogenic parameters.
Keywords Calcium intake
Weight loss
Kidney stones
Vitamin D
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Universidade Federal de São Paulo
Grant number CNPq: 402128/2005-2
Date 2009-06-01
Published in Urological Research. New York: Springer, v. 37, n. 3, p. 133-139, 2009.
ISSN 0300-5623 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 133-139
Origin http://dx.doi.org/10.1007/s00240-009-0187-3
Access rights Closed access
Type Article
Web of Science ID WOS:000266505100003
URI http://repositorio.unifesp.br/handle/11600/31542

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