Blood pressure levels in childhood: probing the relative importance of birth weight and current size

Blood pressure levels in childhood: probing the relative importance of birth weight and current size

Author Strufaldi, Maria Wany L. Autor UNIFESP Google Scholar
Silva, Edina M. K. Autor UNIFESP Google Scholar
Franco, Maria C. P. Autor UNIFESP Google Scholar
Puccini, Rosana F. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Several studies have reported data supporting the idea that an impaired intrauterine environment that deprives the fetus of optimal nutrient delivery results in the predisposition of the fetus to experience cardiovascular and metabolic dysfunction in later life. However, contradictory data still exist. Our purpose was to investigate the effects of both birth weight and weight gain on the risk for high blood pressure levels in 6- to 10-year-old children. This cross-sectional study included 739 children divided into quartiles of birth weight. the mean values of both systolic and diastolic pressure were significantly different between quartiles of birth weight, with increasing blood pressure values as the birth weight decreased (P < 0.001). Covariance analysis adjusting for gender, prematurity, and body mass index (BMI) showed that both systolic and diastolic pressure remained greater in the lowest than in the highest birth weight quartile. Separating those with low and normal birth weight demonstrated that the risk of childhood hypertension was significantly higher among children with low birth weight and current obesity (odds ratio [OR]: 5.0, confidence interval [CI]: 3.3 to 16.1; P = 0.023). the inverse association between birth weight and blood pressure levels appears to be programmed during fetal life, while weight gain during childhood adds to this risk.
Keywords Birth weight
Blood pressure
Obesity
Children
Language English
Date 2009-05-01
Published in European Journal of Pediatrics. New York: Springer, v. 168, n. 5, p. 619-624, 2009.
ISSN 0340-6199 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 619-624
Origin http://dx.doi.org/10.1007/s00431-008-0813-z
Access rights Closed access
Type Article
Web of Science ID WOS:000264321100016
URI http://repositorio.unifesp.br/handle/11600/31492

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