Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo

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dc.contributor.author Lopes, Stefanie C. P.
dc.contributor.author Blanco, Yara C.
dc.contributor.author Justo, Giselle Z. [UNIFESP]
dc.contributor.author Nogueira, Paulo A.
dc.contributor.author Rodrigues, Francisco L. S.
dc.contributor.author Goelnitz, Uta
dc.contributor.author Wunderlich, Gerhard
dc.contributor.author Facchini, Gustavo
dc.contributor.author Brocchi, Marcelo
dc.contributor.author Duran, Nelson
dc.contributor.author Costa, Fabio Trindade Maranhão [UNIFESP]
dc.date.accessioned 2016-01-24T13:52:28Z
dc.date.available 2016-01-24T13:52:28Z
dc.date.issued 2009-05-01
dc.identifier http://dx.doi.org/10.1128/AAC.00693-08
dc.identifier.citation Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 53, n. 5, p. 2149-2152, 2009.
dc.identifier.issn 0066-4804
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31480
dc.description.abstract Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 2149-2152
dc.language.iso eng
dc.publisher Amer Soc Microbiology
dc.relation.ispartof Antimicrobial Agents and Chemotherapy
dc.rights Acesso aberto
dc.title Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo en
dc.type Artigo
dc.contributor.institution Universidade Estadual de Campinas (UNICAMP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution CEPEM
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Univ Estadual Campinas, UNICAMP, Dept Parasitol, Inst Biol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliation Univ Estadual Campinas, UNICAMP, Dept Microbiol & Imunol, Inst Biol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, UNIFESP, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.description.affiliation CEPEM, IPEPATRO, BR-78900970 Porto Velho, RO, Brazil
dc.description.affiliation Univ São Paulo, Dept Parasitol, ICB2, São Paulo, Brazil
dc.description.affiliation Univ Estadual Campinas, Dept Fisiol & Biofis, Inst Biol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliation Univ Estadual Campinas, Lab Quim Biol, Inst Quim, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, UNIFESP, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2004/00638-6
dc.description.sponsorshipID CNPq: 470587/2006-7
dc.identifier.file WOS000265528700060.pdf
dc.identifier.doi 10.1128/AAC.00693-08
dc.description.source Web of Science
dc.identifier.wos WOS:000265528700060



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