Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo

Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth in Vitro and in Vivo

Author Lopes, Stefanie C. P. Google Scholar
Blanco, Yara C. Google Scholar
Justo, Giselle Z. Autor UNIFESP Google Scholar
Nogueira, Paulo A. Google Scholar
Rodrigues, Francisco L. S. Google Scholar
Goelnitz, Uta Google Scholar
Wunderlich, Gerhard Google Scholar
Facchini, Gustavo Google Scholar
Brocchi, Marcelo Google Scholar
Duran, Nelson Google Scholar
Costa, Fabio Trindade Maranhão Autor UNIFESP Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
CEPEM
Universidade de São Paulo (USP)
Abstract Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 2004/00638-6
CNPq: 470587/2006-7
Date 2009-05-01
Published in Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 53, n. 5, p. 2149-2152, 2009.
ISSN 0066-4804 (Sherpa/Romeo, impact factor)
Publisher Amer Soc Microbiology
Extent 2149-2152
Origin http://dx.doi.org/10.1128/AAC.00693-08
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000265528700060
URI http://repositorio.unifesp.br/handle/11600/31480

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