Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates

Potency and Bactericidal Activity of Iclaprim against Recent Clinical Gram-Positive Isolates

Author Sader, Helio S. Autor UNIFESP Google Scholar
Fritsche, Thomas R. Google Scholar
Jones, Ronald N. Google Scholar
Institution JMI Labs
Universidade Federal de São Paulo (UNIFESP)
Tufts Univ
Abstract The in vitro activity of iclaprim, a novel diaminopyrimidine derivative, was evaluated against 5,937 recent gram-positive clinical isolates collected in the United States and Europe. Iclaprim demonstrated potent activity against Staphylococcus aureus (including methicillin-resistant S. aureus [MRSA]), beta-hemolytic Streptococcus spp., and Enterococcus faecalis strains tested. in addition, iclaprim exhibited bactericidal activity against all S. aureus strains tested, including MRSA.
Language English
Sponsor Arpida AG (Reinach, Switzerland)
Date 2009-05-01
Published in Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 53, n. 5, p. 2171-2175, 2009.
ISSN 0066-4804 (Sherpa/Romeo, impact factor)
Publisher Amer Soc Microbiology
Extent 2171-2175
Origin http://dx.doi.org/10.1128/AAC.00129-09
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000265528700066
URI http://repositorio.unifesp.br/handle/11600/31479

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