SWIMMING TRAINING ATTENUATES REMODELING, CONTRACTILE DYSFUNCTION and CONGESTIVE HEART FAILURE in RATS WITH MODERATE and LARGE MYOCARDIAL INFARCTIONS

SWIMMING TRAINING ATTENUATES REMODELING, CONTRACTILE DYSFUNCTION and CONGESTIVE HEART FAILURE in RATS WITH MODERATE and LARGE MYOCARDIAL INFARCTIONS

Author Portes, Leslie Andrews Autor UNIFESP Google Scholar
Saraiva, Roberto Magalhaes Autor UNIFESP Google Scholar
Santos, Alexandra Alberta dos Autor UNIFESP Google Scholar
Tucci, Paulo J. F. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
São Paulo Adventist Univ
Abstract 1. the aim of the present study was to evaluate the effect of swimming on myocardial remodelling after myocardial infarction (MI) in female rats induced by coronary occlusion, which was not performed in sham rats.2. Rats were divided in six groups, three sedentary (sham (SSh; n = 14), moderate infarct (SMI; n = 8) and large infarct (SLI; n = 10)) and three trained (sham (TSh; n = 16), moderate infarct (TMI; n = 9) and large infarct (TLI; n = 8)) groups. Training (8 weeks, 60 min/day, 5 days/week) was initiated 4 weeks after MI or sham operation. Training did not affect mortality rate, but attenuated the increases in atrial/bodyweight (SSh: 0.07 +/- 0.02; TSh: 0.07 +/- 0.02; SMI: 0.11 +/- 0.03; TMI: 0.09 +/- 0.03; SLI: 0.17 +/- 0.09; TLI: 0.10 +/- 0.05 mg/g) and right ventricular/bodyweight (SSh: 0.15 +/- 0.02; TSh: 0.17 +/- 0.02; SMI: 0.17 +/- 0.07; TMI: 0.20 +/- 0.03; SLI: 0.29 +/- 0.13; TLI: 0.22 +/- 0.08 mg/g) ratios. Myocardial infarction increased pulmonary and myocardial water content in infarcted sedentary animals, whereas no changes were observed in trained infarcted rats. Sedentary infarcted rats showed inotropic and lusitropic depression proportional to the size of the infarct (SSh > SMI > SLI), whereas no differences were noted in trained rats (TLI = TMI = TSh). Indeed, in sedentary rats there was depression of +dT/dt (SSh: 68 +/- 25; TSh: 72 +/- 21; SMI: 53 +/- 20; TMI: 77 +/- 30; SLI: 33 +/- 15; TLI: 57 +/- 22 g/mm(2) per s) and -dT/dt (SSh: 33 +/- 13; TSh: 36 +/- 11; SMI: 24 +/- 5; TMI: 35 +/- 11; SLI: 15 +/- 4; TLI: 32 +/- 11 g/mm(2) per s) compared with trained rats.3. in conclusion, swimming clearly favoured post-MI cardiac remodelling, attenuated myocardial hypertrophy, contractile and relaxation dysfunction and prevented pulmonary congestion.
Keywords contractile dysfunction
heart failure
myocardial infarction
swimming training
Language English
Date 2009-04-01
Published in Clinical and Experimental Pharmacology and Physiology. Malden: Wiley-Blackwell Publishing, Inc, v. 36, n. 4, p. 394-399, 2009.
ISSN 0305-1870 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 394-399
Origin http://dx.doi.org/10.1111/j.1440-1681.2008.05070.x
Access rights Closed access
Type Article
Web of Science ID WOS:000265549100007
URI http://repositorio.unifesp.br/handle/11600/31443

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