Evaluation of Nephrolithiasis in Autosomal Dominant Polycystic Kidney Disease Patients

Evaluation of Nephrolithiasis in Autosomal Dominant Polycystic Kidney Disease Patients

Author Nishiura, Jose Luiz Autor UNIFESP Google Scholar
Neves, Rodrigo F. C. A. Autor UNIFESP Google Scholar
Eloi, Samara Rodrigues Moreira Autor UNIFESP Google Scholar
Cintra, Susan M. L. F. Autor UNIFESP Google Scholar
Ajzen, Sergio Aron Autor UNIFESP Google Scholar
Heilberg, Ita Pfeferman Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background and objectives: Nephrolithiasis (LIT) is more prevalent in patients with autosomal dominant polycystic kidney disease (ADPKD) than in the general population. Renal ultrasonography may underdetect renal stones because of difficulties imposed by parenchymal and/or cyst wall calcifications.Design, setting, participants, & measurements: A total of 125 patients with ADPKD underwent ultrasonography and unenhanced computed tomography (CT) scan, routine blood chemistry, and spot and 24-h urine collections.Results: CT scan detected calculi in 32 patients, including 20 whose previous ultrasonography revealed no calculi. the percentage of hypocitraturia was high but not statistically different between patients with ADPKD+LIT or ADPKD. Hyperuricosuria and distal renal tubular acidosis were less prevalent but also did not differ between groups, whereas hyperoxaluria was significantly higher in the former. Hypercalciuria was not detected. Renal volume was significantly higher in patients with ADPKD+LIT versus ADPKD, and a stepwise multivariate logistic regression analysis showed that a renal volume >= 500 ml was a significant predictor of LIT in patients with ADPKD and normal renal function, after adjustments for age and hypertension.Conclusions: CT scan was better than ultrasonography to detect LIT in patients with ADPKD. Larger kidneys from patients with ADPKD were more prone to develop stones, irrespective of the presence of metabolic disturbances.
Language English
Date 2009-04-01
Published in Clinical Journal of the American Society of Nephrology. Washington: Amer Soc Nephrology, v. 4, n. 4, p. 838-844, 2009.
ISSN 1555-9041 (Sherpa/Romeo, impact factor)
Publisher Amer Soc Nephrology
Extent 838-844
Origin http://dx.doi.org/10.2215/CJN.03100608
Access rights Open access Open Access
Type Conference paper
Web of Science ID WOS:000264937900026
URI http://repositorio.unifesp.br/handle/11600/31404

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