A randomized study of low-dose conjugated estrogens on sexual function and quality of life in postmenopausal women

A randomized study of low-dose conjugated estrogens on sexual function and quality of life in postmenopausal women

Author Gast, Michael J. Google Scholar
Freedman, Murray A. Google Scholar
Vieweg, Alberta J. Google Scholar
De Melo, Nilson R. Google Scholar
Girao, Manoel J. B. C. Autor UNIFESP Google Scholar
Zinaman, Michael J. Google Scholar
Dyspareunia Study Grp Google Scholar
Institution Wyeth Pharmaceut
Med Coll Georgia
Inst Saude & Ben Estar da Mulher
Universidade Federal de São Paulo (UNIFESP)
Loyola Univ Chicago
Abstract Objective: To evaluate the effects of combined vaginal and oral low-dose estrogen plus progestogen therapy (EPT) on the frequency and severity of dyspareunia, sexual function, and quality of life in recently postmenopausal women.Methods: This outpatient, double-blind, randomized, placebo-controlled trial enrolled 285 healthy, sexually active postmenopausal women aged 45 to 65 years. Women received either one daily oral low-dose conjugated estrogens (0.45 mg)/medroxyprogesterone (1.5 mg) tablet for six 28-day cycles along with I g conjugated estrogens vaginal cream (0.625 mg), intravaginally for the first 6 weeks of the trial or a placebo cream and placebo tablet. Efficacy was evaluated using the McCoy Female Sexuality Questionnaire, self-reported daily diary cards, the Brief Index of Sexual Functioning-Women (BISF-W), and the Women's Health Questionnaire.Results: the EPT group had a significant decrease in the frequency of dyspareunia compared with baseline and placebo in an analysis of responses to the McCoy Female Sexuality Questionnaire. Also, EPT was associated with a significant improvement in a woman's level of sexual interest, frequency of orgasm, and pleasure of orgasm. There was no effect of EPT use on coital frequency. the EPT group had significant improvement in receptivity/initiation and relationship satisfaction, although not in other BISF-W domains, versus placebo (BISF-W analysis) and significant improvement versus placebo on most Women's Health Questionnaire responses.Conclusions: EPT provided a statistically significant improvement compared with placebo in dyspareunia, sexual experience, and quality of life as measured in this study. in general, EPT also improved self-reported sexual perception and enjoyment significantly compared with placebo.
Keywords Hormone therapy
Conjugated estrogens
Sexual function
Quality of life
Language English
Sponsor Wyeth, Collegeville, PA
Date 2009-03-01
Published in Menopause-the Journal of the North American Menopause Society. Philadelphia: Lippincott Williams & Wilkins, v. 16, n. 2, p. 247-256, 2009.
ISSN 1072-3714 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 247-256
Origin http://dx.doi.org/10.1097/gme.0b013e318184c440
Access rights Closed access
Type Article
Web of Science ID WOS:000264064100007
URI http://repositorio.unifesp.br/handle/11600/31368

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