Regulation of inflammation in the adipose tissue in cancer cachexia: effect of exercise

Regulation of inflammation in the adipose tissue in cancer cachexia: effect of exercise

Author Lira, Fabio Santos de Autor UNIFESP Google Scholar
Rosa Neto, José Cesar Autor UNIFESP Google Scholar
Zanchi, Nelo E. Google Scholar
Yamashita, Alex S. Google Scholar
Lopes, Renato Delascio Autor UNIFESP Google Scholar
Lopes, Antonio Carlos Autor UNIFESP Google Scholar
Batista, Miguel L. Google Scholar
Seelaender, Marilia Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract The paraneoplastic syndrome of cachexia is considered a degenerative chronic inflammatory disease, being deeply related to the increase of pro-inflammatory factors, especially tumour necrosis factor alpha (TNF-alpha). It is known that the adipose tissue is affected by cachexia and contributing with the secretion of pro-inflammatory factors which reach the adjacent tissues and the circulation. the effect of proinflammatory factors is balanced by the effect of anti-inflammatory factors, such as interleukin 10 (IL-10). the IL-10/TNF-alpha ratio has been recently postulated as a marker for the assessment of the degree of inflammation, which correlates with disease-associated morbidity and mortality. in order to counteract inflammation in chronic disease, out-group has currently adopted chronic endurance exercise in models of cancer cachexia and chronic heart failure. Since it is clear that white adipose tissue is strongly implicated in the secretion of both pro- and anti-inflammatory factors in disease, we chose to address its contribution to cachexia-related inflammation and the effect of endurance training on the capacity of cytokine expression and secretion by this tissue. Our results show an enhancement of IL-10 adipose tissue content, and increased IL-10/TNF-alpha. ratio induced by endurance training. the mechanisms are discussed. Copyright (C) 2009 John Wiley & Sons, Ltd.
Keywords cancer cachexia
adipose tissue
physical exercise
Language English
Date 2009-03-01
Published in Cell Biochemistry and Function. Chichester: John Wiley & Sons Ltd, v. 27, n. 2, p. 71-75, 2009.
ISSN 0263-6484 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 71-75
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000264118100002

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