Reticulated platelets and thrombopoietin in schistosomiasis patients

Reticulated platelets and thrombopoietin in schistosomiasis patients

Author Koepke-Aguiar, L. A. Google Scholar
dE Leon, C. P. Google Scholar
Shigueoka, D. C. Google Scholar
Lourenco, D. M. Google Scholar
Kouyomdjian, M. Google Scholar
Borges, D. R. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Schistosomiasis mansoni is a non-cirrhotic liver disease. in cirrhosis patients with portal hypertension, a decreased number of reticulated platelets associated with increased thrombopoietin serum levels were reported. We previously reported a 120/nl platelet cutoff level as a marker of clinically significant portal hypertension in schistosomiasis patients. To evaluate reticulated platelet counts and thrombopoietin serum levels (TPO) in schistosomiasis patients and correlate them with portal hypertension markers. Thirty-three schistosomiasis patients without co-morbidities were endoscopically classified as those with (n = 19) or without (n = 14) clinically significant portal hypertension. Flow cytometric determination of reticulated platelets was performed using CD41 antibody and thiazol orange. Ultrasonographic examinations were performed according to the Niamey protocol. TPO and hyaluronic acid serum levels were determined in duplicate using ELISA methods. the platelet number of 120/nl discriminates the two groups with 100% accuracy and 100% positive and negative predictive values, and correlates with spleen length and portal and splenic vein diameters. Differences in reticulated platelets and hyaluronic acid serum levels between both groups were significant (P = 0.025 and 0.012, respectively), but thrombopoietin serum levels were not (P = 0.769). Schistosomiasis patients with portal hypertension have increased reticulated platelets associated with normal TPO serum levels.
Keywords Platelets
portal hypertension
reticulated platelets
schistosomiasis
thrombopoietin
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number CNPq: 520281/96-9
FAPESP: 02/5260-6
Date 2009-02-01
Published in International Journal of Laboratory Hematology. Malden: Wiley-Blackwell Publishing, Inc, v. 31, n. 1, p. 69-73, 2009.
ISSN 1751-5521 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 69-73
Origin http://dx.doi.org/10.1111/j.1751-553X.2007.01005.x
Access rights Closed access
Type Article
Web of Science ID WOS:000262466300008
URI http://repositorio.unifesp.br/handle/11600/31311

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