Trypanosoma cruziand myoid cells from seminiferous tubules: interaction and relation with fibrous components of extracellular matrix in experimental Chagas' disease

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dc.contributor.author Pereira Carvalho, Luiz Otavio
dc.contributor.author Abreu-Silva, Ana Lucia
dc.contributor.author Hardoim, Daiana de Jesus
dc.contributor.author Tedesco, Roberto Carlos [UNIFESP]
dc.contributor.author Mendes, Veronica Goncalves
dc.contributor.author Goncalves da Costa, Sylvio Celso
dc.contributor.author Calabrese, Katia da Silva
dc.date.accessioned 2016-01-24T13:52:15Z
dc.date.available 2016-01-24T13:52:15Z
dc.date.issued 2009-02-01
dc.identifier http://dx.doi.org/10.1111/j.1365-2613.2008.00592.x
dc.identifier.citation International Journal of Experimental Pathology. Malden: Wiley-Blackwell Publishing, Inc, v. 90, n. 1, p. 52-57, 2009.
dc.identifier.issn 0959-9673
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31306
dc.description.abstract The main transmission route of Trypanosoma cruzi is by triatomine bugs. However, T. cruzi is also transmitted through blood transfusion, organ transplantation, ingestion of contaminated food or fluids, or is congenital. Sexual transmission, although suggested since the discovery of Chagas' disease, has remained unproven. Sexual transmission would require T. cruzi to be located at the testes and ovaries. Here we investigated whether T. cruzi is present in the gonads of mice infected with 10(4)T. cruzi trypomastigotes from the CL strain. Fourteen days after experimental infection, histopathological examination showed alterations in the extracellular matrix of the lamina propria of the seminiferous tubules. Furthermore, amastigotes were present in seminiferous tubules, within myoid cells, and in the adjacencies of the basal compartment. These results indicate that T. cruzi is able to reach seminiferous tubule lumen, thus suggesting that Chagas' disease could potentially be transmitted through sexual intercourse. Complementary studies are required to demonstrate that Chagas' disease can be transmitted by coitus. en
dc.description.sponsorship Instituto Oswaldo Cruz, FIOCRUZ/Ministry of Health, Brazil
dc.format.extent 52-57
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof International Journal of Experimental Pathology
dc.rights Acesso restrito
dc.subject collagenous en
dc.subject experimental Chagas' disease en
dc.subject extracellular matrix en
dc.subject myoid cells en
dc.subject seminiferous tubules en
dc.title Trypanosoma cruziand myoid cells from seminiferous tubules: interaction and relation with fibrous components of extracellular matrix in experimental Chagas' disease en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Fiocruz MS
dc.contributor.institution Univ Estadual Maranhao
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Fiocruz MS, Inst Oswaldo Cruz, Lab Imunomodulacao & Protozool, Fundacao Oswaldo Cruz, BR-21045900 Rio de Janeiro, Brazil
dc.description.affiliation Univ Estadual Maranhao, Dept Pathol, Sao Luis, Maranhao, Brazil
dc.description.affiliation Fiocruz MS, Inst Oswaldo Cruz, Lab Biol Estrutural, BR-21045900 Rio de Janeiro, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Morfol, Disciplina Anat Topograf & Descrit, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Morfol, Disciplina Anat Topograf & Descrit, São Paulo, Brazil
dc.identifier.doi 10.1111/j.1365-2613.2008.00592.x
dc.description.source Web of Science
dc.identifier.wos WOS:000262516200006



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