Trypanosoma cruziand myoid cells from seminiferous tubules: interaction and relation with fibrous components of extracellular matrix in experimental Chagas' disease

Trypanosoma cruziand myoid cells from seminiferous tubules: interaction and relation with fibrous components of extracellular matrix in experimental Chagas' disease

Author Pereira Carvalho, Luiz Otavio Google Scholar
Abreu-Silva, Ana Lucia Google Scholar
Hardoim, Daiana de Jesus Google Scholar
Tedesco, Roberto Carlos Autor UNIFESP Google Scholar
Mendes, Veronica Goncalves Google Scholar
Goncalves da Costa, Sylvio Celso Google Scholar
Calabrese, Katia da Silva Google Scholar
Institution Fiocruz MS
Univ Estadual Maranhao
Universidade Federal de São Paulo (UNIFESP)
Abstract The main transmission route of Trypanosoma cruzi is by triatomine bugs. However, T. cruzi is also transmitted through blood transfusion, organ transplantation, ingestion of contaminated food or fluids, or is congenital. Sexual transmission, although suggested since the discovery of Chagas' disease, has remained unproven. Sexual transmission would require T. cruzi to be located at the testes and ovaries. Here we investigated whether T. cruzi is present in the gonads of mice infected with 10(4)T. cruzi trypomastigotes from the CL strain. Fourteen days after experimental infection, histopathological examination showed alterations in the extracellular matrix of the lamina propria of the seminiferous tubules. Furthermore, amastigotes were present in seminiferous tubules, within myoid cells, and in the adjacencies of the basal compartment. These results indicate that T. cruzi is able to reach seminiferous tubule lumen, thus suggesting that Chagas' disease could potentially be transmitted through sexual intercourse. Complementary studies are required to demonstrate that Chagas' disease can be transmitted by coitus.
Keywords collagenous
experimental Chagas' disease
extracellular matrix
myoid cells
seminiferous tubules
Language English
Sponsor Instituto Oswaldo Cruz, FIOCRUZ/Ministry of Health, Brazil
Date 2009-02-01
Published in International Journal of Experimental Pathology. Malden: Wiley-Blackwell Publishing, Inc, v. 90, n. 1, p. 52-57, 2009.
ISSN 0959-9673 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 52-57
Origin http://dx.doi.org/10.1111/j.1365-2613.2008.00592.x
Access rights Closed access
Type Article
Web of Science ID WOS:000262516200006
URI http://repositorio.unifesp.br/handle/11600/31306

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