Transitory Myocardial Ischemia in Patients with Vascular Lower Limb Amputation Relationship with Long-Term Atherothrombotic Events

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dc.contributor.author McNeill Ingham, Sheila Jean [UNIFESP]
dc.contributor.author Chamlian, Therezinha Rosane [UNIFESP]
dc.contributor.author Souza, Jose Marconi de [UNIFESP]
dc.contributor.author Stefanini, Edson [UNIFESP]
dc.contributor.author Azevedo, Rudyney [UNIFESP]
dc.contributor.author Mussi, Aurelia [UNIFESP]
dc.contributor.author Carvalho, Antonio Carlos [UNIFESP]
dc.date.accessioned 2016-01-24T13:52:15Z
dc.date.available 2016-01-24T13:52:15Z
dc.date.issued 2009-02-01
dc.identifier http://dx.doi.org/10.1097/PHM.0b013e3181951c98
dc.identifier.citation American Journal of Physical Medicine & Rehabilitation. Philadelphia: Lippincott Williams & Wilkins, v. 88, n. 2, p. 114-118, 2009.
dc.identifier.issn 0894-9115
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/31305
dc.description.abstract Objective: To evaluate the prevalence of asymptomatic transitory myocardial ischemia during scintigraphy among amputees of vascular etiology as well as to ascertain correlation with atherothrombotic events during long-term follow-up.Design: A cohort, mean follow-up of 2.1 yrs study was performed in an outpatient rehabilitation clinic with 58 lower limb vascular amputees who were referred for rehabilitation, asymptomatic for coronary heart disease. Patients were evaluated for myocardial ischemia by dipyridamole scintigraphy, and occurrence of severe cardiovascular events (death, acute myocardial infarction, stroke, and peripheral ischemia with hospitalization) was assessed.Results: of the 58 patients, 26 (44.8%) had positive dipyridamole myocardial scintigraphy for transitory myocardial ischemia. During follow-up, 12 subjects (20.7%), mainly diabetic patients (83%), registered a serious cardiovascular event, with 9 of 12 events having occurred in those who had tested positive for transitory ischemia on scintigraphy (P < 0.025). There were five deaths (19.2%) in those with a positive scintigraphy and a single death (3.1%) in those with a negative dipyridamole test, although the Kaplan-Meier survival curve and Cox regression were not significant (P = 0.09 and 0.1, respectively).Conclusions: We found that 44.8% of patients with vascular lower limb amputation, asymptomatic for coronary disease, tested positive on myocardial scintigraphy for transitory myocardial ischemia. in a mean follow-up of 2.1 yrs, there was 10.3% of atherothrombotic events/year, with a higher death toll in those patients with positive scintigraphy. en
dc.format.extent 114-118
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof American Journal of Physical Medicine & Rehabilitation
dc.rights Acesso restrito
dc.subject Amputees en
dc.subject Atherosclerosis en
dc.subject Acute Coronary Syndromes en
dc.subject Myocardial Perfusion Scintigraphy en
dc.subject Peripheral Arterial Disease en
dc.title Transitory Myocardial Ischemia in Patients with Vascular Lower Limb Amputation Relationship with Long-Term Atherothrombotic Events en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Phys Med & Rehabil, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Cardiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Phys Med & Rehabil, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Cardiol, São Paulo, Brazil
dc.identifier.doi 10.1097/PHM.0b013e3181951c98
dc.description.source Web of Science
dc.identifier.wos WOS:000262739900005



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