Epstein-Barr virus detection in invasive and pre-invasive lesions of the uterine cervix

Epstein-Barr virus detection in invasive and pre-invasive lesions of the uterine cervix

Author Santos, Nelly Beatriz Modos Autor UNIFESP Google Scholar
Villanova, Fabiola Elizabeth Google Scholar
Andrade, Priscila Maria Google Scholar
Ribalta, Julisa Autor UNIFESP Google Scholar
Focchi, José Autor UNIFESP Google Scholar
Otsuka, Audrey Yumi Google Scholar
Silva, Ismael Dale Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract In the present study, our aim was to investigate whether EBV DNA could be found in association with invasive and pre-invasive cervical cancer lesions. We hypothesize that EBV is not merely a commensal agent when present in malignant cervical lesions. DNA was extracted from cervical scrapings followed by nested PCR-based amplification. the patients were 66 women with high grade cervical intraepithelial neoplasia and 14 women with invasive cervical cancer. the control group consisted of 89 women with a normal Pap smear and colposcopy as well as a negative HPV DNA test. Analysis of our results, in conjunction with the work of other authors, leads us to propose that EBV is not merely a commensal agent when present in malignant cervical lesions. the presence of DNA from EBV is significantly associated with cervical cancer.
Keywords Epstein-Barr virus
cervical cancer
HPV
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 99/03366-6
Date 2009-02-01
Published in Oncology Reports. Athens: Spandidos Publ Ltd, v. 21, n. 2, p. 403-405, 2009.
ISSN 1021-335X (Sherpa/Romeo, impact factor)
Publisher Spandidos Publ Ltd
Extent 403-405
Origin http://dx.doi.org/10.3892/or_00000236
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000262679300019
URI http://repositorio.unifesp.br/handle/11600/31274

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